Flow Chemistry European Summit 2024
Date: Monday, 25 March 2024 - Tuesday, 26 March 2024
Location: Hilton Rotterdam, The Netherlands
Confirmed Speakers
Anca Roibu, Postdoctoral Fellow, Transilvania University of Brasov
Anna Slater, Professor of Chemistry and Royal Society University Research Fellow, University of Liverpool
David Ricart Fort, PhD Student, Escola Politècnica Superior d'Enginyeria de Manresa (EPSEM), Barcelona
Gianvito Vilé, Tenure-Track Assistant Professor in Chemical Engineering, Politecnico di Milano
Julio Cezar Pastre, Associate Professor, University of Campinas – UNICAMP
Marcus Baumann, Assistant Professor, School of Chemistry, University College Dublin
Nina Hartrampf, Assistant Professor, University of Zurich
Rajat Pandey, Postdoctoral Fellow, Nelson Mandela University
Stephen Hilton, Associate Professor, University College London School of Pharmacy
Andrew Mansfield, Flow Chemistry Leader, Syrris
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz -- Keynote Speaker
Floris Rutjes, Professor, Institute for Molecules and Materials, Radboud University, The Netherlands
Heidrun Gruber-Wölfler, Associate Professor, Graz University of Technology
Katia Martina, Associate Professor of Organic Chemistry, Università degli Studi di Torino
Martina Letizia Contente, Tenure-Track Assistant Professor, University of Milan
Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium -- Keynote Speaker
Thomas Wirth
Professor, Cardiff University -- Keynote Speaker
Anita Maguire
Professor of Pharmaceutical Chemistry, University College Cork -- Keynote Speaker
Christophe Len, Professor, Chimie ParisTech, CNRS
François-Xavier Felpin, Professor, University of Nantes
Jean-Christophe Monbaliu, Professor of Organic Chemistry, Center for Integrated Technology and Organic Synthesis (CiTOS), University of Liège -- Keynote Speaker
Manuel Nuño, Chief Scientific Officer, Vapourtec Ltd.
Maurizio Benaglia, Full Professor of Organic Chemistry, Dipartimento di Chimica, Università degli Studi di Milano
Paul Watts
Distinguished Professor and Research Chair, Nelson Mandela University -- Conference Chairperson
Stephan Weiß, Global Technology Manager, ASIGA
Overview of the Conference
SelectBIO Flow Chemistry European Summit 2024 brings together researchers and industry participants from both academia and industry focusing on technology and innovation in the Flow Chemistry and Related fields.
Basic research trends in Flow Chemistry together with Applications in Sustainable Technologies, Photochemistry and Electrochemistry are discussed.
Advances in Flow Chemistry as well as Instrumentation Design such as 3D-Printed Reactors will be addressed. Importantly, the deployment of Flow Chemistry-based Approaches in the Pharmaceutical Industry will be highlighted.
There is an Extensive International Perspective at this Conference with Speakers, Poster Presenters, Sponsors, and Exhibitors from Europe, US, and Around the World. Running alongside the conference will be an exhibition covering the latest technological advances and associated products and services from leading solution providers within this field.
Registered delegates will have full access to the co-located and concurrent conference tracks to mix-and-match presentations and maximize networking:
• Flow Chemistry European Summit 2024
• Innovations in Microfluidics and 3D-Printing 2024
There are ample opportunities for networking, partnering and business development and this ensures a very cost-effective conference trip.
The Exhibit Hall is Co-Located with the Conference Tracks for Excellent Networking.
Call for Posters
Agenda Topics
You can present your research in a Poster at this conference.
Please submit your abstract via the Submissions Page
of this website.
Poster Presentation Abstract Submission Deadline:
29 February 2024
• Devices and Engineering for Flow Chemistry and Instrumentation Platforms
• Electrochemistry and Photochemistry in Flow
• Engineering and 3D-Printing of Reactors in Flow Chemistry
• Flow Chemistry in Space and Space Chemistry
• Industrial Processes and API Manufacturing
• Machine Learning and AI in Flow Chemistry
• Microfluidics and its Impact on the Development of Flow Chemistry
• Multistep Synthesis and New Reaction Classes Enabled in Flow Format
Call for Posters
Jeff Fan
Exhibition Manager - SelectBIO
E-mail: Jeff@selectbioconferences.com
3 for 2 Offer on Delegate Registrations
SelectBIO are offering 3 Delegate Registrations for the price of 2 on all delegate passes. To take advantage of this offer, please contact us by email, phone or click the Contact Us button below. Looking for more than 3 Delegate Passes? Contact us for more information on our special rates for large groups.
Any questions or assistance during registration, please call us at: +1 (510) 857-4865 or e-mail us at: Contact SelectBIO
Gold Sponsors
Exhibitors
If you require any information about exhibiting or sponsoring at one of our events please contact Jeff Fan using the information below:
Jeff Fan
Exhibition Manager - SelectBIO
Email: Jeff@selectbioconferences.com
Why Sponsor or Exhibit at a SelectBIO Conference?
Specialists: SelectBIO doesn't organize conferences in shipping, accountancy, textiles etc. – just biotechnology and life sciences. Many of our staff have bioscience qualifications and many years of experience. So, we speak your language and understand your needs.
Superior Customer Service: Our sales team will take care of you with specialist advice and customized packages. We don’t forget you after you sign on the bottom line either as our customer service dept. will alert you to all the things you need to think about up to and during the event itself.
You don't need to rent carpeting, wifi, furniture -- our exhibits come completely ready-to-use with plenty of food and beverages throughout the conference for everyone. So you can focus on networking and business development, and let us worry about logistics details.
Flow Chemistry European Summit 2024 Venue
SelectBIO is delighted to host the Flow Chemistry European Summit 2024 at the Hilton Rotterdam, Rotterdam, The Netherlands.
HILTON ROTTERDAM
Weena 10
3012 CM Rotterdam, The Netherlands
The Hilton Rotterdam is a 7-minute walk from Rotterdam Centraal Station with fast connections to Amsterdam-Schiphol Airport, Antwerp, Brussels, Brussels Airport, and Paris.
Rotterdam also is easily accessible from London via the Eurostar.
All conference sessions, exhibition as well as networking reception will be held at the Hilton Rotterdam.
SelectBIO has negotiated discounted pricing for conference attendees at the Hilton Rotterdam:
Single Room 179€ per night
Double Room 199€ per night
This rate includes buffet breakfast, wired/wifi internet in the room and 9% VAT but does not include 6.5% city tax per night.
To make your Hotel Reservations Online:
For any hotel reservation-related issues, or if you need any help with hotel bookings, please contact:
Jeff Fan
Events Manager, SelectBIO
E-mail: Jeff@selectbioconferences.com
SelectBIO has NOT authorized ANY third party company to assist in hotel bookings or reservations for the conference. Please do NOT do business with any third party companies. If in doubt, please contact Jeff Fan immediately to clarify.
Register to this conference and also enjoy the following co-located events at no extra charge.
Training Courses
If you would like to submit a proposal for an oral or poster presentation at this meeting, please fill out the form below required for your submission.
Successful applicants will be provided with all necessary information.
Abstract Content:
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Written in English
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Written in the third person
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Include title, name(s) and affiliation(s) of the authors
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Between 100 - 200 words
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Suitable for direct publication in the proceedings pack and on the website
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Related to the subject of the conference
Agenda Topics
- • Devices and Engineering for Flow Chemistry and Instrumentation Platforms
• Electrochemistry and Photochemistry in Flow
• Engineering and 3D-Printing of Reactors in Flow Chemistry
• Flow Chemistry in Space and Space Chemistry
• Industrial Processes and API Manufacturing
• Machine Learning and AI in Flow Chemistry
• Microfluidics and its Impact on the Development of Flow Chemistry
• Multistep Synthesis and New Reaction Classes Enabled in Flow Format
Copyrights
The presenting author/person who submitted the abstract assumes full responsibility of the content of the abstract and we assume that all co-authors are aware of this content. Please note that your biography, summary and abstract may be used on this website and conference materials.
Anca Roibu, Postdoctoral Fellow, Transilvania University of Brasov
Anca Roibu Biographical Sketch
Dr. Anca Roibu studied chemical engineering in Bucharest (Romania). She received a joint master degree in applied spectroscopy from Leipzig University (Germany), Bologna University (Italy), and Lille 1 University (France) and a PhD in Chemical Engineering from KU Leuven (Belgium). Since 2022, she has been a postdoctoral fellow at Transilvania University of Brasov, Romania, working on building an automated screening platform for immobilized photocatalysts. Her research interests lie in designing and characterizing photo microreactors and light sources, flow photocatalysis, and digitalization.
Andrew Mansfield, Flow Chemistry Leader, Syrris
Andrew Mansfield Biographical Sketch
After graduating with a degree in Applied Chemistry Andrew moved into the research sector working for a range of Pharmaceutical companies including Roche, Napp, Parke-Davis and Pfizer. From an early point in his career he began to specialize in new enabling chemical technologies and automation specializing in high throughput synthesis and purification and flow chemistry.
At Pfizer Andrew led the flow chemistry initiative working across research projects and process groups to integrate flow chemistry in Pfizer's workflow. During this time that Andrew undertook an industrial secondment in Prof. Steve Ley's group developing his knowledge in the flow field. After the Pfizer (Sandwich) site closed Andrew took his expertise and ran his own consultancy company developing batch to flow processes, training and working with flow chemistry apparatus manufactures to develop their technology and develop in-house applications. Andrew moved to Syrris in early 2015 first in a technical role to develop flow chemistry applications, moving into Product Management before taking the position as Head of Flow Chemistry Products expanding his role to cover Syrris’ complete flow chemistry portfolio.
Anita Maguire, Professor of Pharmaceutical Chemistry, University College Cork
Anita Maguire Biographical Sketch
Anita is a graduate of UCC (BSc 1985, PhD 1989). Following postdoctoral research in Namur, Belgium then in Exeter, UK, Anita returned to UCC in 1991 to establish a research team in synthetic organic chemistry and has played a strategic role at the interface with the pharmaceutical industry. She is a Co-PI in the national SFI Centre SSPC. She was elected as a Member of the Royal Irish Academy in 2014 and appointed RIA Vice President in 2019. She was an Adjunct Professor in the University of Bergen, 2011-16. She was VP Research & Innovation in UCC 2011-21. Throughout her career she has been actively engaged nationally in strategic R&I policy development including as a member of the Advisory Science Council. Since 2015 she is the inaugural Chair of the National Forum on Research Integrity, leading national policy development and implementation in this area.
Anna Slater, Professor of Chemistry and Royal Society University Research Fellow, University of Liverpool
Anna Slater Biographical Sketch
Prof Anna Slater received her PhD in supramolecular chemistry from the University of Nottingham in 2011. Following postdoctoral positions in porphyrin self-assembly and porous organic cage materials she took up a Royal Society-EPSRC Dorothy Hodgkin Fellowship in 2016 and a Royal Society University Research Fellowship in 2021, both at the University of Liverpool. She was promoted to Chair of Chemistry in 2022. Anna developed an interest in flow chemistry during her PDRA positions, recognizing that flow technology has a lot to offer the supramolecular chemist; exploiting flow processes for enhanced control of chemistry is now a central theme of her work. Her research interests include molecular materials, enabling technology and organic synthesis and self-assembly.
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz
Oliver Kappe Biographical Sketch
C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of the Center for Continuous Flow Synthesis and Processing (CC FLOW) at the Research Center Pharmaceutical Engineering GmbH (RCPE). He received his diploma (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his „Habilitation“ in 1998 in organic chemistry and was appointed Associate Professor in 2000. Since 2011 he is Professor for „Technology of Organic Synthesis“ (Organische Synthesetechnologie) at the Institute of Chemistry at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, T. Takahashi, 2008), the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010) and the Federal University of Rio de Janeiro (Rio de Janeiro, Brazil, 2013-2015).
Professor Kappe has an extensive general experience and a 25 year track record in synthetic and physical organic chemistry, process intensification using batch microwave technology and flow chemistry/microreaction technology, communicated in ~400 scientific publications (Research ID, WoS h-Index 72). For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification technologies. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 100.000 € Houska Prize in addition to a number of other awards. In 2015 he was named Fellow of the Royal Society of Chemistry.
C. Oliver Kappe is the Founding Editor and current Editor-in-Chief of the Journal of Flow Chemistry (Springer) and a board member of the Flow Chemistry Society. In addition he has been an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH, 2003-2007) and has served/serves on the Editorial/Advisory Boards of Green Chemistry, Reaction Chemistry & Engineering (RSC), Current Opinion in Green and Sustainable Chemistry (Elsevier), ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer), Journal of Heterocyclic Chemistry (Wiley-VCH) and a number of other journals.
Christophe Len, Professor, Chimie ParisTech, CNRS
Christophe Len Biographical Sketch
Prof. Dr. Christophe Len received his Ph.D. in 1995 from the Université de Picardie Jules Verne followed by a post-doctoral fellow at the University of Hull (UK). In 1997, he became assistant Professor at UPJV and was promoted to full Professor in 2004 at the Université de Poitiers (France). In 2010, he moved as full Professor to the Université de Technologie de Compiègne – UTC (France). Since 2017, he has developed his research at Chimie ParisTech (France). He has published ~ 230 original publications and review articles, 10 book chapters, and 11 patents. Among recent awards and recognition to his scientific career, he was promoted Honorary Professor of the University of Hull, England (2012–2018), Honorary Professor at the University of Delhi, India (2022), Honorary Professor at the Xi’an Jiaotong University, China (2022-2025) and Fellow of the Royal Society of Chemistry (FRSC, 2015). In 2017, he was honored with the 2017 Glycerine Innovation Award sponsored by the American Cleaning Institute and the National Biodiesel Board. His current research explores organic chemistry and catalysis applied to biomass.
David Ricart Fort, PhD Student, Escola Politècnica Superior d'Enginyeria de Manresa (EPSEM), Barcelona
David Ricart Fort Biographical Sketch
I graduated in nanoscience and nanotechnology at the Universitat Autònoma de Barcelona (UAB). Then I did a master in natural resources and environmental engineering at the Escola Politècnica Superior d'Enginyeria de Manresa (EPSEM). My doctoral thesis starts at the end of 2021 at EPSEM. The objective is to monitor using a 3D printed modular FIA system with an optical detector the concentration of key analytes in a bioreactor for a bioleaching process to recover copper in mobile phones. At the moment, even if it is already published, the system for Fe(III) is already done and now I will present the one for Cu(II). My research interests go with the objective of recycling everything, that is, that nothing can be considered as waste but as a resource.
Floris Rutjes, Professor, Institute for Molecules and Materials, Radboud University
Floris Rutjes Biographical Sketch
Floris Rutjes received his PhD from the University of Amsterdam in 1993 with profs. W.N. Speckamp and H. Hiemstra and conducted postdoctoral research with prof. K.C. Nicolaou at The Scripps Research Institute, La Jolla, USA. In 1999 he became full professor in organic synthesis at Radboud University, Nijmegen. He was awarded amongst others the Gold Medal of the Royal Netherlands Chemical Society (KNCV, 2002), the AstraZeneca Award for Research in Organic Chemistry (2003), Most Entrepreneurial Scientist of the Netherlands (2008) and Chemistry Europe Fellow (2022). He is elected member of the Netherlands Academy of Engineering and the Academia Europaea. Currently, he is director of the Institute for Molecules and Materials at Radboud University and vice-president of the European Chemical Society (EuChemS).
François-Xavier Felpin, Professor, University of Nantes
François-Xavier Felpin Biographical Sketch
François-Xavier Felpin was born in France. After earning his Ph.D. at the University of Nantes (France) in 2003, he pursued postdoctoral studies at The Ohio State University (USA). In 2004 he joined the University of Bordeaux as an Assistant Professor and he received his habilitation in 2009. In fall 2011 he moved to the University of Nantes where he was promoted full Professor. Prof. Felpin was a junior member of the Institut Universitaire de France (2012-2017). His research interests include catalysis, material chemistry and automated flow chemistry.
Gianvito Vilé, Tenure-Track Assistant Professor in Chemical Engineering, Politecnico di Milano
Gianvito Vilé Biographical Sktech
Prof. Dr. Gianvito Vilé graduated with honors in Chemical Engineering from Politecnico di Milano and received his PhD from ETH Zurich. He is currently a tenure-track assistant professor at Politecnico di Milano. His research focuses on the understanding of the structure and reactivity of single-atom catalysts, and on the design of continuous-flow catalytic methods. He has received numerous awards for his research, including the ETH Zurich Medal for outstanding doctoral thesis, the Dimistris N. Chorafas Award from the Weizmann Institute of Sciences in Israel, and the Felder Award from the Bracco pharmaceutical company. He was also selected among the most influential researchers by leading journals of the American Chemical Society, Royal Society of Chemistry, and Institute of Physics. Twitter: @VileGroup, website: vile-researchgroup.com
Heidrun Gruber-Wölfler, Associate Professor, Graz University of Technology
Heidrun Gruber-Wölfler Biographical Sketch
Assoc.Prof. Heidrun Gruber-Woelfler studied technical chemistry at Graz University of Technology, Austria, with a focus on chemical engineering. After her PhD dealing with organometallic catalysis and molecular modelling, she did her Post-Doc in the area of continuous processes for the synthesis and purification of active pharmaceutical ingredients.
Since 2014 she is the head of the research group “Continuous Synthesis and Processes” at the Institute of Process and Particle Engineering (http://ippt.tugraz.at/), TU Graz, and since 2016 the deputy head of this institute. Furthermore, Heidrun Gruber-Woelfler is key researcher at the Research Center Pharmaceutical Engineering (RCPE, (http://www.rcpe.at/) GmbH, and since July 2017 the Deputy Director of the Center of Continuous Flow Synthesis and Processing (CCFlow) in Graz. Her current projects deal with flow chemistry, heterogeneous (bio)catalysis and continuous processes, as well as reactor design including additive manufacturing, real-time analyses, automation and self-optimization.
Jean-Christophe Monbaliu, Professor of Organic Chemistry, Center for Integrated Technology and Organic Synthesis (CiTOS), University of Liège
Jean-Christophe Monbaliu Biographical Sketch
Jean-Christophe M. Monbaliu, born in Brussels, Belgium, studied chemistry at the Université catholique de Louvain, Belgium, where he received his Ph.D. in Organic Chemistry. In 2008, he started a postdoc at the Faculty of Bioscience Engineering of the Ghent University, Belgium, where he was later appointed as a postdoctoral associate of the Research Foundation-Flanders. In 2010, he was awarded a Belgian American Educational Foundation fellowship that triggered his relocation to the USA. He joined the Center for Heterocyclic Compounds at the University of Florida, Gainesville, USA. In 2012, he was appointed at the Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. In 2013, he came back to Belgium and settled at the University of Liège. Monbaliu created the Center for Integrated Technology and Organic Synthesis (CiTOS), where he is currently developing new methods for organic synthesis using micro- and mesofluidic reactors. CiTOS is the first European Corning® Advanced-Flow™ reactor (AFR) qualified lab.
Julio Cezar Pastre, Associate Professor, University of Campinas – UNICAMP
Julio Cezar Pastre Biographical Sketch
Prof. Dr. Julio C. Pastre obtained his PhD in 2009 at the University of Campinas – UNICAMP. He then worked as a research scientist at Rhodia-Solvay before moving back to UNICAMP for postdoctoral studies with Professor Ronaldo A. Pilli. In 2012, he joined the group of Professor Steven V. Ley at the University of Cambridge. Two years later, Julio established his independent research group at UNICAMP and recently became Associate Professor. He is now the Head of the Department of Organic Chemistry. Recently, he was recognized as an ‘Emerging Investigator’ by Reaction Chemistry & Engineering and RSC Advances and a ‘New Talent from the Americas’ by RSC Medicinal Chemistry. His research interest focuses on the development of new synthetic methods using enabling technologies for the synthesis of high added-value compounds from renewable sources, including platform molecules, new chemicals, and APIs.
Katia Martina, Associate Professor of Organic Chemistry, Università degli Studi di Torino
Katia Martina Biographical Sketch
Dr. Katia Martina, studied chemistry and pharmaceutical technology at the University of Turin (Italy) where she received the Ph.D. in Chemistry. She joined the Pharmacia and Upjohn research center in Nerviano (Milan) as Research Scientist in the chemistry Department and after 7 years she move back to the University of Turin in the Department of Drug Science and Technology where she was appointed associate Professor in Organic Chemistry in 2020. Her research interests lie on catalysis, grafting of organic/inorganic material and innovative synthetic procedures carried out under non-conventional techniques. Her expertise is centered in microwave-assisted chemistry, sonochemistry and flow chemistry.
Manuel Nuño, Chief Scientific Officer, Vapourtec Ltd.
Manuel Nuño Biographical Sketch
Dr. Manuel Nuño completed his MChem at Universidad de Zaragoza, Spain and York University, UK moving to University of Bath, UK to undertake his PhD in photocatalysis under the supervision of Dr Richard J. Ball.
Following completion of his PhD, Manuel advanced his process improvement skills during three years as process development chemist in food manufacturing industry working to improve the performance of large scale batch and flow chemical processes involving extraction, purification and crystallisation of sugars. Early in 2019 Manuel moved to Vapourtec ltd as a research scientist, offering applications and chemistry support to customer and product development teams. Projects he has worked with include, photochemistry in flow, flow peptide synthesis, organometallic chemistry in flow and continuous electrochemical oxidation of natural products.
Marcus Baumann, Assistant Professor, School of Chemistry, University College Dublin
Marcus Baumann Biographical Sketch
Graduated from Philipps-University Marburg 2007
- PhD with Prof. Steve V. Ley (Cambridge) in 2010
- Humboldt postdoc with Prof. Larry E. Overman (UC Irvine) 2011-2013
- postdoc with Prof. Ian R. Baxendale (Durham) 2013-2017
- since 2017 Assistant Professor for Continuous Flow Chemistry at University College Dublin
Martina Letizia Contente, Tenure-Track Assistant Professor, University of Milan
Martina Letizia Contente Biographical Sketch
Martina Letizia Contente is a Tenure-Track Assistant Professor at the University of Milan. She graduated in Pharmacy at the same University, where she obtained also her PhD in Medicinal Chemistry. During her years as post doc she had the opportunity to work in different international environments increasing her expertise in the development of intensified and sustainable flow-biobased processes for the preparation of bioactive compounds and pharma/food ingredients. Among her research interests enzyme discovery, protein immobilization and stabilization for continuous processing are the most important.
Maurizio Benaglia, Full Professor of Organic Chemistry, Dipartimento di Chimica, Università degli Studi di Milano
Maurizio Benaglia Biographical Sketch
Maurizio Benaglia, since 2015 Full Professor of Organic Chemistry, at the Università degli Studi di Milano, is author of more than 230 publications on scientific international journals. His main research interests are the development of novel synthetic methodologies and their application to the synthesis of chiral pharmaceutical products, the design of new chiral organocatalysts, the study of visible light-driven reactions and organic electrosynthesis, to develop innovative and sustainable chemical processes, exploring the use of novel packed-bed and monolithic catalytic reactors, exploiting the unique features of such devices in stereoselective transformations in flow processes and studying organocatalyzed reactions in mini- and microreactors under continuous-flow conditions, taking advantage also of 3D-printing technologies. He was awarded by the Italian Chemical Society of the Ciamician medal (2001), and the Piero Pino Medal, he has been the director of the International School “Corbella” (2013-2017) and since 2017 he is the Director of the International School of Process Chemistry (ISPROCHEM). He is also Editor of the book “Catalyst Immobilization: Methods and Applications” (Wiley, 2020) and of the book “Organocatalysis -Stereoselective Reactions and Applications in Organic Synthesis” (DeGruyter, 2021), and Coordinator of national and international financed projects.
Nina Hartrampf, Assistant Professor, University of Zurich
Nina Hartrampf Biographical Sketch
Nina Hartrampf studied chemistry and biochemistry at Ludwig-Maximilians-Universität Munich (Germany) and obtained her PhD in the field of natural product synthesis and chemical biology in the group of Dirk Trauner. She then moved to the group of Brad Pentelute at the Massachusetts Institute of Technology (USA) as a postdoctoral researcher, where she worked on the optimization of flow-based peptide synthesis using an automated synthesis platform.
In 2020, she moved to the University of Zurich (Switzerland) as an assistant professor (tenure track). Her research group focuses on the development of new tools for flow-based peptide synthesis as well as the chemical synthesis of post-translationally modified peptides and proteins. Her work has been recognized with the 2019 Bert Schram Award from the American Peptide Society, the 2021 Bachem Award for Peptide Science, and the 2022 Thieme Journals Award.
Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California
Noah Malmstadt Biographical Sketch
Noah Malmstadt is Professor at the University of Southern California. He received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. Malmstadt is the recipient of a 2012 Office of Naval Research Young Investigator award. His research focuses on microfluidic strategies to facilitate material fabrication and biophysical analysis. He has pioneered the integration of ionic liquids as solvents in droplet microreactors and the application of microfluidic systems to synthesizing biomimetic cell membranes. Microfluidic analytical techniques he has developed include methods for measuring the permeability of cell membranes to druglike molecules and techniques for measuring ionic currents through membrane proteins.
Paul Watts
Distinguished Professor and Research Chair, Nelson Mandela University
Paul Watts Biographical Sketch
Prof Paul Watts started his career as a lecturer at the University of Hull in 2002, being promoted to full professor in 2011. At the University of Hull he led the micro reactor and flow technology group. In February 2013, he moved to Nelson Mandela University to hold the Distinguished Professorship and Research Chair in Microfluidic Bio/Chemical Processing. He has published of over 120 highly cited papers. He strongly believes that scientists should conduct research that impacts society; the biggest project underway involves the local production of key drugs as the morbidity and mortality from major diseases are much more devastating in Africa than in other regions of the world. The vision is that new technology will be used within South Africa to manufacture generic drugs; this could create jobs and a new manufacturing industry within the country.
Rajat Pandey, Postdoctoral Fellow, Nelson Mandela University
Rajat Pandey Biographical Sketch
Rajat Pandey conducted his PhD with Prof. R. Vijaya Anand at the Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India. His thesis was entitled "Metal-free approaches for the synthesis of N-heterocycles and diarylmethanes under batch as well as continuous-flow conditions." Since 2023 he has been working as a postdoctoral research fellow at Nelson Mandela University with Prof Paul Watts on the synthesis of APIs in flow reactors.
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium
Simon Kuhn Biographical Sketch
Simon Kuhn received his Diploma in Chemical Engineering from TU Munich and his PhD from ETH Zurich. After a stay as post-doctoral fellow at the Massachusetts Institute of Technology (MIT), he joined the Department of Chemical Engineering at University College London as assistant professor. In 2014, he was appointed as professor in the Department of Chemical Engineering at KU Leuven. His research interests lie in the characterization of transport processes in complex flows using experiments and modeling, scaling-up microchemical systems, and design of novel flow reactors.
Stephan Weiß, Global Technology Manager, ASIGA
Stephan Weiß Biographical Sketch
Dr. Stephan Weiß holds a doctorate in polymer chemistry and dived into 3D printing after completing his studies. In 2014, he was the first German reseller to represent Asiga.
Since 2017, Stephan has been working directly for Asiga, passing on his knowledge to new dealers in the form of training, coordinating cooperation with the numerous material partners (already over 500 validated materials) and doing process and application optimization (leading to developments like the Low Force Tray, UltraGloss Tray, Fast Print Mode, Separation Detection, etc.).
Stephen Hilton, Associate Professor, University College London School of Pharmacy
Stephen Hilton Biographical Sketch
Dr Stephen Hilton is an Associate Professor at UCL School of Pharmacy. Dr Hilton's diverse research interests range from medicinal chemistry, scale-up synthesis and new technology with an emphasis on the applications of 3D printing and Virtual Reality in Synthetic Chemistry and Pharmaceutical applications. Dr Stephen Hilton is the Inventor of the IKA FLOW - continuous flow reactor, which is partnered and sold by IKA. The IKA FLOW features unique 3D printed reactors at its core that were developed in the Hilton group and the group’s current focus is on the application of 3D printing towards new continuous flow technology, catalysis, methodology and linking of the technology to Virtual Reality.
Thomas Wirth, Professor, Cardiff University
Thomas Wirth Biographical Sketch
Thomas Wirth is professor of organic chemistry at Cardiff University. After studying chemistry in Bonn, he obtained his PhD and at the Technical University of Berlin. After a postdoctoral stay at Kyoto University, he started his independent research at the University of Basel before taking up his current position at Cardiff University in 2000. He was invited as a visiting professor to several places. Thomas Wirth was awarded the Werner-Prize from the New Swiss Chemical Society, the Furusato award from JSPS London, the Wolfson Research Merit Award from the Royal Society and the Bader Award from the Royal Society of Chemistry. In 2016 he was elected as a fellow of The Learned Society of Wales. His main interests of research concern stereoselective electrophilic reactions, oxidative transformations with hypervalent iodine reagents including mechanistic investigations and organic synthesis performed in microreactors.
08:00
25 March 2024
Conference Entrance
Conference Registration, Materials Pick-Up and Coffee
08:50
25 March 2024
Coolsingel Room
Session Title: Conference Opening Session -- Flow Chemistry 2024
09:00
25 March 2024
Coolsingel Room
Conference Chairperson Welcome
Paul Watts
Distinguished Professor and Research Chair, Nelson Mandela University
Welcome and Introduction by Conference Chairperson and Vision of Continuous Flow - Local API Manufacturing
Africa has a variety of formulation companies, however the active pharmaceutical ingredients are generally imported. This results in increased drug costs, making medications unaffordable to many patients in Africa.
When micro reactor technology and flow chemistry was introduced it was seen as a research and development tool, however it is now being used to produce large quantities of product. The drivers being increased safety, higher yields and purity as well as reduced production cost. There is now a range of commercial reactors on the market, which means that most companies are investigating this technology to rapidly screen reactions, leading to the identification of reaction conditions that are suitable for use at a production level.
COVID-19 caused drug shortages around the world, demonstrating the need for local production capacity. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of cases studies will be presented.
09:45
25 March 2024
Coolsingel Room
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria
Enantioselective Organocatalysis in Flow Mode
Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated to benefit considerably from the merits of continuous processing and microreactor technology. Over the past few years, continuous flow enantioselective organocatalysis has grown into a mature field and has found diverse applications in asymmetric synthesis of pharmaceutically active substances. In this lecture flow chemistry-based approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of immobilized metal-free organocatalysis to introduce asymmetry in continuously operated systems will be presented. Single-step processes, interrupted multistep flow syntheses and uninterrupted one-flow syntheses from our group will be discussed.
10:30
25 March 2024
Exhibit Hall
Mid-Morning Coffee Break and Networking in the Exhibit Hall
11:00
25 March 2024
Coolsingel Room
Anita Maguire, Professor of Pharmaceutical Chemistry, University College Cork, Ireland
Selective Thermal Deprotection of N-Boc Protected Amines in Continuous Flow
Among the various protecting groups employed to protect amines during synthetic steps, Boc protection has proved particularly effective. While removal of Boc protecting groups under acidic conditions is one of the most frequently encountered transformations within the chemical and pharmaceutical community, there are limitations including selectivity, compatibility with other acid labile groups, vigorous off-gassing and foaming. Thermal N-Boc deprotection of a range of amines is readily effected in continuous flow, in the absence of an acid catalyst. While the optimum results were obtained in methanol or trifluoroethanol, deprotection can be effected in a range of solvents of different polarities. Sequential selective deprotection of N-Boc groups has been demonstrated, as exemplified by effective removal of an aryl N-Boc group in the presence of an alkyl N-Boc group.
11:30
25 March 2024
Coolsingel Room
Julio Cezar Pastre, Associate Professor, University of Campinas – UNICAMP, Brazil
Generation and Use of Reactive Species Under Continuous Flow Conditions
A distinct advantage when performing transformations in continuous flow is the ability to handle reactive or short-lived intermediates and safely determine the destiny of these species without isolation or exposure to these hazardous materials. This ability to control reactive intermediates affords greater flexibility in processing, by defining product outcomes or aiding scale-up. In this talk, I will present some contributions to the generation of reactive intermediates such as acylketenes, unstabilised diazo compounds, radicals and further exploitation of their chemistry to the synthesis of key building blocks.
12:00
25 March 2024
Coolsingel Room
Anna Slater, Professor of Chemistry and Royal Society University Research Fellow, University of Liverpool, United Kingdom
Supramolecular Chemistry in Flow: Challenges and Opportunities
Molecular materials and supramolecular systems have great potential in separation and sensing applications, but their synthesis and scale-up is challenging because their formation and self-assembly is strongly influenced by reaction environment. We use three approaches to control the formation of 3D molecular species and their assembly into molecular materials: 1) tuning the building blocks; 2) varying the interaction strength between building blocks, and 3) controlling the process by which they are made.
In this talk I will outline the third strategy with our work on porous organic cages (POCs), macrocycles, and organic materials, showing how continuous flow chemistry and non-thermal plasma approaches are useful tools for supramolecular chemists.
12:30
25 March 2024
Exhibit Hall
Networking Buffet Lunch in the Exhibit Hall -- Networking with Colleagues, Engage with Exhibitors
13:50
25 March 2024
Coolsingel Room
Session Title: Emerging Methods and Approaches in the Flow Chemistry Field
14:00
25 March 2024
Coolsingel Room
Gianvito Vilé, Associate Professor in Chemical Engineering, Politecnico di Milano
Continuous Photocatalytic C-X Couplings in Polymer-Based Microreactors
14:30
25 March 2024
Coolsingel Room
Nina Hartrampf, Assistant Professor, University of Zurich
Flow-based Methods for Chemical Peptide and Protein Synthesis
The field of biopharmaceuticals is rapidly expanding, requiring new methods for the on-demand production of chemically modified peptides and proteins. This chemical synthesis involves the iterative formation of amide bonds and requires high yields for efficient incorporation of each individual amino acid. Solid-phase peptide synthesis (SPPS) has been a standard method for chemical peptide and protein production for the past 60 years, but its outcome can be highly dependent on the peptide sequence synthesized. One issue that often arises is the aggregation of growing peptide chains on the solid support, which can lead to incomplete couplings ("difficult sequences”), and this effect generally correlates with low synthesis yields. Previous research into this sequence-dependent phenomenon was limited by the lack of high-throughput analytical methods, thus impeding systematic analysis.
As opposed to batch-SPPS, flow-SPPS not only accomplishes rapid synthesis of tailored peptides and proteins but also enables the collection of in-line analytical data that gives new insights into sequence-dependent events such as aggregation. In this presentation, various parameters affecting aggregation will be analyzed, and the development of new computational methods, technological solutions, and synthetic tools to reduce the sequence dependence in SPPS will be disclosed.
15:00
25 March 2024
Coolsingel Room
François-Xavier Felpin, Professor, University of Nantes, France
Enhancing Optimization on a Robotic-Flow Platform: Integrating Statistical Filtering with Bayesian Methods
We present a simple and comprehensive mixed variable optimization strategy based on sequential sampling, statistical filtering, and black box optimization, coupled with an automated micromole scale flow platform to perform complex optimizations.
15:30
25 March 2024
Exhibit Hall
Mid-Afternoon Coffee Break and Networking in the Exhibit Hall
16:00
25 March 2024
Coolsingel Room
Jean-Christophe Monbaliu, Professor of Organic Chemistry, Center for Integrated Technology and Organic Synthesis (CiTOS), University of Liège, Belgium
Exploring the Synergy Between a priori Computational Intelligence and Flow Process Development
The assets of flow chemistry for (re)exploring forbidden chemistries and new process windows are now well established. However, when experimental data is lacking, developing a flow process can sometimes be cumbersome, time- and resource-intensive. This talk illustrates our efforts to lessen the experimental burden and to accelerate the development of new reactions and flow processes. Our work lies at the interface of computational chemistry and flow organic chemistry, and converges toward a quantum assistant that merges computational chemistry and machine learning. This predictive model scouts for the vast and new chemical space that flow chemistry provides. Not only will this assistant help you to decide whether your reaction is doable in flow, but it also provides the best conditions for the preparation of libraries within minutes.
16:30
25 March 2024
Coolsingel Room
Andrew Mansfield, Flow Chemistry Leader, Syrris, United Kingdom
Compound Library Generation using Flow Chemistry
Pursuing new classes of compounds which can be used as new medicines for treatment of diseases is not a simple task. Researchers often create new active compounds from scratch, through a laborious process involving synthesizing and testing thousands of compounds aiming to find those suitable to be tested in human beings.
In this context, Medicinal Chemistry is an interdisciplinary science at the interface of chemical biology, pharmacology, and medicine playing a fundamental role to define novel therapeutic approaches and discover new drugs. One of the major purposes of medicinal chemistry is the design and synthesis of new lead compounds for druggable targets. This process involves the synthesis and testing of often tens of thousands of exploratory compounds to disclose one new drug. From a medicinal chemist’s view point the synthesis of diverse compounds to screen is a key part of the drug discovery process. Chemists are constantly looking for alternative solutions to solve limitations of chemical synthesis, to increase the tools in their toolbox. The adoption of enabling chemical technologies as automation and flow systems have enabled chemists to shorten iterative learning cycles through early discovery to production and to the point of care.
The content of the presentation will cover a range of topic areas around how flow chemistry impacts and enables the generation of new, diverse compound libraries through the use of automated flow chemistry techniques to accelerate the early drug discovery process. While chemists at each stage of the drug discovery and development process will see specific benefits when implementing continuous flow techniques, the pharmaceutical industry’s desire to ultimately move towards the continuous manufacturing of future drugs means all stages of the drug lifecycle need to be aware of – and potentially implementing – continuous flow.
17:00
25 March 2024
Coolsingel Room
Manuel Nuño, Chief Scientific Officer, Vapourtec Ltd., United Kingdom
Advances in Continuous Flow: Reactor Technology, Pump Capabilities and Solid-Phase Synthesis
Continuous stirred tank reactors (CSTR) offer an alternative to plug flow reactors when used in series as a cascade of reactors. CSTRs are well suited for biphasic reactions and processes involving solids, such as heterogeneous catalysis or the formation of insoluble intermediates. Reaction products can be separated from starting materials and residence time distributions can be well controlled. In this presentation, Manuel will discuss the different approaches to reaction optimisation when using CSTR or tubular reactors for a biphasic reaction as well as a Suzuki coupling. Vapourtec recently launched the SF-10+, a heated peristaltic pump, designed to heat and pump fluids up to 80 Degrees C. By working at these temperatures, we can deal with reagents that are solid at room temperature but liquid at higher temperatures, supersaturated solutions and even high viscosity fluids, otherwise impossible to handle. Fast flow peptide synthesis (FF-SPPS) and their applications in both lab and pilot scale. By working in single-pass continuous flow and controlling the packing density, peptide synthesis can be scaled more efficiently than batch processes while accessing valuable real-time data, such as UV spectra. When combining both UV spectral data and resin volume change, the precise moment of aggregation of peptides can be identified in the sequence. By way of example, Manuel will show the optimization of GLP-1 analogues at 50 µmol scale and the direct scale-up with a 300X factor, with identical purity.
17:30
25 March 2024
Coolsingel Room
Thomas Wirth, Professor, Cardiff University, United Kingdom
Opportunities for Iodine Reagents in Flow Synthesis
The development of catalytic reactions based on stoichiometric reactions using iodine-based reagents will be discussed. Novel chiral reagents and catalysts allow the easy synthesis of versatile scaffolds as synthetic building blocks as well as applications towards total synthesis. The direct electron transfer at electrode surfaces is one of the prototypical green technologies of the future and the use of microreactors further advances and simplifies that technology. The use of a robust and flexible flow microreactor for electrochemistry will be presented for the facile generation of iodine(III) reagents. Examples of stereoselective iodine(III)-mediated electrochemical reactions are being discussed.
18:00
25 March 2024
JAG Bar
Networking Reception with Dutch Beer in the JAG Bar - Network and Engage with Colleagues in a Social Setting
19:00
25 March 2024
Close of Day 1 Main Conference Programming
08:00
26 March 2024
Exhibit Hall
Morning Coffee and Networking in the Exhibit Hall
08:20
26 March 2024
Coolsingel Room
Session Title: 3D-Printing in Flow Chemistry -- Joint Session with Innovations in Microfluidics and 3D-Printing.
Chaired by Professor Noah Malmstadt
08:30
26 March 2024
Coolsingel Room
Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California, United States of America
3D-Printing of Microfluidics
09:00
26 March 2024
Coolsingel Room
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium, Belgium
Microfluidic Approaches for the Controlled Synthesis of Particles
Microfluidic flow reactors offer several advantages compared to conventional batch reactors, such as improved control, increased performance, and enhanced process safety. The integration of crystallization in these devices has remained difficult, as crystals tend to clog the flow channels. Both active (with an externally applied force, e.g. ultrasound) and passive methods (without external forces, e.g. multiphase flow) have been proposed to tackle this issue. Many crystallization processes rely on the addition of seeds to induce secondary nucleation. Seeding in continuous microfluidic reactors is rarely done, as the seeds are continuously flushed out and the clogging susceptibility increases. This contribution presents a seeded microfluidic nucleation section which can be used for continuous cooling crystallization. The performance of the off-line continuous seeding platform is established via the seed delivery efficiency, a measure for the seed transport through the seeding module, for constant and oscillatory flows. Second, the yields of seeded and unseeded crystallization are evaluated in the presence and absence of microbubbles. A statistically significant increase in the net yield was obtained when comparing unseeded and seeded crystallization, which can be attributed to the increased nucleation rates because of secondary nucleation. It is shown that also in the presence of seeds, the addition of microbubbles increases the productivity. Advancing to zeolite synthesis, a seeded milli-fluidic crystallizer is developed, which also features low frequency ultrasound integration, which is known to speed up crystallization kinetics during the synthesis thanks to the formation and collapse of cavitation bubbles, creation of local hotspots, intense mixing and enhanced dissolution of the amorphous species, which shorten induction time and increase growth rate. This system enables to compare the synthesis conditions in batch, silent and sonicated, and in continuous, silent and sonicated, in terms of residence time, crystallinity, and solid yield. Secondly, the change in the product characteristics, such as morphology, crystal size and crystal size distribution, pore size and its distribution in the framework is characterized. This work provides valuable insights into the design and operation of continuous crystallization processes.
09:30
26 March 2024
Coolsingel Room
Pierre Blanchet, R&D Equipment Manager, Kloé, France
Dilase 3D: Combining Very High Resolution and Large Size Fabrication Capability
Over the last 15 years, Kloé company developed a complete range of equipment dedicated to UV lithography applications, in perfect agreement with the microfabrication requirements in Microfluidics. Thus, Kloé company did the bet, in the early 2000, that the development of researches and industry in Microfluidics would rapidly grow. So that, over the same time, Kloé company continuously followed and exchanged with the Microfluidics community to first well understand and then anticipate its needs in terms of microfabrication techniques and performance, in order to enable fabricating from simple to more demanding microfluidic chips like Lab on a Chip / Organ on a Chip. Among a very large range of 12 different machines, covering from soft lithography / masking systems to very high resolution direct laser writers particularly suitable for fast prototyping, high aspect ratio as well as thick layers laser processing, Kloe introduces one of its latest innovations that is Dilase3D : a 3D-Printer specifically developed to meet the expectations for 3D-printing in Microfluidics. Typically elaborated from the specifications of researches in Microfluidics and Medical Sciences, that were looking for one tool enabling to both fabricate large volume pieces, but still with very high-resolution patterning capabilities, this equipment also demonstrated more recently its capability to combine different materials for the fabrication of one piece/object, that multiplies its capabilities to fabricate very demanding and ever more complex microchips/microstructures. This way, we ensure our partners to benefit from the one of the most performing and cost-effective 3D-printing solutions in that domain, in agreement with their expected level of performance and their available budget.
10:00
26 March 2024
Coolsingel Room
Stephen Hilton, Associate Professor, University College London School of Pharmacy, United Kingdom
The Development and Use of 3D Printed Reactors in Flow and Photoflow Chemistry and the Collaborative Photoflow System – the Proteus Aether
In this talk we will describe our research into 3D printing and our research into the applications of various 3D printed reactors in flow chemistry, flow electrochemistry and flow photochemistry. We will also describe research from other groups into their use across a range of chemistry examples, demonstrating how the use of these low-cost reactors can make flow chemistry more accessible and reduce the barrier to entry for chemists in this key technology. As part of our research into 3D printing, we will also describe our research into the Proteus Aether – a low cost 3D printed continuous flow system designed to make photoflow chemistry more accessible and accurate, with digital telemetry and its use by others.
10:30
26 March 2024
Exhibit Hall
Mid-Morning Coffee Break and Networking in the Exhibit Hall
11:00
26 March 2024
Coolsingel Room
Anca Roibu, Postdoctoral Fellow, Transilvania University of Brasov, Romania
In-Flow Screening of Immobilized Photocatalysts in 3D Printed Microreactors
Flow microreactors are promising devices for screening photocatalyst activity due to reaction times in the range of minutes compared to several hours in conventional photoreactors and the ease of connection to inline analytical techniques. A microfluidic platform which consists of parallel microreactors and a rotating multi-wavelength LED light source was developed and its operation was automated. The microreactors were manufactured by 3D printing, the photocatalysts were immobilized as thin films, and the photocatalytic activity was investigated by applying successively various illumination conditions. The microfluidic platform was used for screening the activity of TiO2-based photocatalysts for degrading organic pollutants (e.g. imidacloprid, phenol).
11:30
26 March 2024
Coolsingel Room
Stephan Weiß, Global Technology Manager, ASIGA, Germany
ASIGA Advancing 3D Printed Microfluidics
ASIGA is a leader in reliable and precise DLP 3D Printers. In this talk we will show you how to leverage our open material system and voxel-level control over all parameters in our 3D printers to create cutting edge Microfluidic Chips.
12:00
26 March 2024
Coolsingel Room
Camila Betterelli Giuliano, Microfluidics Innovation Specialist, Microfluidics Innovation Center, France
Can Microfluidics be Truly User-Friendly?
Microfluidics is said to become the backbone of the bio-revolution. Yet, the highest reported barrier to adoption of the technology is its complex usability. Let’s be honest, biology is already complex enough. So, how can we expect researchers to harvest the microfluidic power of new in vitro models if they don’t have the headspace to assemble Lego-like setups? Enough with the meters of tubing and million connectors, come see how design is meeting science.
12:30
26 March 2024
Coolsingel Room
Eden Microfluidics Technology Spotlight Presentation
13:00
26 March 2024
Exhibit Hall
Networking Buffet Lunch in the Exhibit Hall -- Networking with Colleagues, Engage with Exhibitors, View Posters
13:55
26 March 2024
Coolsingel Room
Session Chair: Professor Paul Watts
14:00
26 March 2024
Coolsingel Room
Katia Martina, Associate Professor of Organic Chemistry, Università degli Studi di Torino, Italy
Copper-Catalyzed Continuous-Flow Transfer Hydrogenation In Ethylene Glycol
Conventional protocols are increasingly being replaced by new efficient synthetic processes that use safer chemicals, naturally abundant solvents, atom economy and efficient catalytic systems to yield the desired product with sustainability, scalability and high chemical efficiency. Flow approaches have been demonstrated to show great merit in safety and speed, as well as in their increased yields and quality. Given the importance of this process in both industry and academia, it is not surprising that a vast number of catalytic flow-chemistry hydrogenation protocols have been reported over the last decade with noble metals and that reductions of nitro benzene to aniline and alkyne to alkenes are largely studied. Non-noble metals have also been of great interest to the scientific community due to their economic and environmental advantages. The preparation of a robust supported catalyst that is made up of copper nanoparticles on celite for the selective transfer hydrogenation under continuous flow of nitroarenes and alkynes will be presented. The method is efficient and environmentally benign thanks to the absence of hydrogen gas and precious metals. Long-term stability studies show that the catalytic system is able to achieve very high conversion (> 99%) when working for long time. The versatility of the transfer hydrogenation system has been tested using representative examples with moderate-to-excellent yields being obtained.
14:30
26 March 2024
Coolsingel Room
Marcus Baumann, Assistant Professor, School of Chemistry, University College Dublin, Ireland
From Improving Known Reactions to the Discovery of New Reactivity Exploiting Flow
Through reactor miniaturization flow chemistry offers superb control over reaction conditions and thus lends itself towards the safe generation and immediate consumption of high-energy intermediates that would not be viable in analogous batch reactions. Our group1-5 and others have exploited this advantage to improve both the yield and selectivity of a number of synthetically important transformations. This talk will showcase several flow reactions including lithiations and photochemical processes that demonstrate the value of flow in this context, for instance for the generation and use of benzynes, acyl radicals and [1.1.1]propellane. The discovery of new chemical space aid by flow synthesis will be discussed as well.
15:00
26 March 2024
Coolsingel Room
Martina Letizia Contente, Tenure-Track Assistant Professor, University of Milan, Italy
Flow Biocatalysis for the Synthesis of Natural Compounds
Due to healthy life style of modern society, the preference for bio-compounds derived from natural sources is rapidly expanding. On the other hand, according with both European and US regulation (EMA and FDA) processing natural starting material with biocatalytic approaches let the commercialization of the final product as natural too, thus increasing its market value. In this scenario, the combination of biocatalysts, (whole cells and cell-free enzymes) with flow facilities, represents an emerging technology to enhance reaction productivity and sustainability. Through immobilization techniques the biocatalysts can be easily integrated in flow chemistry reactors, while their stability under operational conditions is dramatically improved. Moreover, due to the catalyst recovery and reuse for several reaction cycles cost-effective processes can be developed. Valuable natural molecules such as aroma-compounds, potent antioxidants as well as bioactive molecules have been successfully prepared merging the advantages of flow reactors with the specificity and benign conditions of biocatalysts. This strategy representing an alternative route for natural compound production in addition to plant extraction, and promoting a responsible care of natural resources is extremely attractive for a series sectors in particular food, pharmaceutical and cosmetic industries.
15:30
26 March 2024
Exhibit Hall
Mid-Afternoon Coffee Break and Networking in the Exhibit Hall
16:00
26 March 2024
Coolsingel Room
Christophe Len, Professor, Chimie ParisTech, CNRS, France
Flow Chemistry and Biomass Valorization - An Emerging Green Technology
The principles of sustainable development, bio-economy and circular economy are gaining ground in the synthesis of industrially important molecules. Furfural, glycerol and derivatives, which serve as central platform molecules, are the subject of various research efforts aimed at optimizing their conversion for the synthesis of valuable compounds. In line with the prevailing push for green chemistry and sustainable development, chemists have recently been at the forefront of innovative catalytic reactions using continuous flow processes combined or not with alternative technologies such as microwave, ultrasound, ball milling…. This progressive shift underscores a commitment to advancing environmentally friendly practices in the field of chemical synthesis. This study presents recent breakthroughs in the continuous production of bio-based chemicals derived from furfural, glycerol and derivatives. These intermediates and target chemicals are synthesized from biomass or carbohydrates using both homogeneous and heterogeneous catalysts. Various reaction parameters, including temperature, catalyst and feedstock loadings, and solvent types, have been meticulously optimized over time. The design, synthesis, and physicochemical properties of these derivatives are comprehensively elucidated.
16:30
26 March 2024
Coolsingel Room
Floris Rutjes, Professor, Institute for Molecules and Materials, Radboud University, The Netherlands
Pragmatic Continuous Flow Solutions for Larger Scale Synthesis Reactions
This presentation will highlight some recent examples of continuous flow chemistry that were developed to solve synthetic challenges in the corresponding batch reactions, including separation of E- and Z-isomers, synthesis of complex sialic acids and determination of reaction kinetics.
17:00
26 March 2024
Coolsingel Room
David Ricart Fort, PhD Student, Escola Politècnica Superior d'Enginyeria de Manresa (EPSEM), Barcelona
Automated Cu(II) Monitoring over a Wide Concentration Range with Microflow Injection Analysis System Employing Modular 3D-Printed Platforms
An automated microflow injection analysis (microFIA) system has been developed for continuous monitoring of Cu(II) in a bioreactor using a colorimetric method. The system combines different 3D printed modules. The reagents used are hydroxylamine and neocuproine.
17:30
26 March 2024
Coolsingel Room
Maurizio Benaglia, Full Professor of Organic Chemistry, Dipartimento di Chimica, Università degli Studi di Milano, Italy
Photoredox Catalytic Reactions in Continuous Flow Reactors
In the last few years, the use of continuous-flow systems has been widely exploited in the synthesis of chiral APIs (active pharmaceutical ingredients). Furthermore, the combination of organocatalysis and photochemistry may give a straightforward access to molecules which would otherwise be difficult to attain. Organocatalytic in flow reactions in (micro)-mesoreactors and in CSTRs (continuous stirred tank reactors) will be presented. A visible-light catalyzed cyclization of bis(enones) to afford enantiomerically enriched cyclopentane rings, a metallaphotoredox strategy for the synthesis of tryptamines and the use of packed-bed reactors in light-driven reactions will be discussed.
18:00
26 March 2024
Coolsingel Room
Heidrun Gruber-Wölfler, Associate Professor, Graz University of Technology, Austria
Combining (photo)Biocatalysis with Continuous Flow: Efficient Biotransformations in 3D Printed Reactors
Biocatalysis has gained a lot of popularity in recent years as an eco-friendly alternative to conventional catalysis in synthetic chemistry. Enzymes have a variety of advantages, including as low toxicity, little environmental effect, high activity in moderate settings, and good selectivity. Nevertheless, new and innovative approaches are still required in order to increase the stability of biocatalysts and make biocatalytic processes in continuous flow commercially feasible. In this contribution the design of continuous, inexpensive, and stable biocatalytic processes for a more sustainable synthesis of fine chemicals will be discussed. In the first part, the design of a continuous automated process to evaluate the efficiency of the model enzyme PAD (phenolic acid decarboxylase) covalently immobilized on 3D printed supports [1] will be presented. For a Design of Experiments (DoE) evaluation, an automated control setup was operated by a Python-based application in order to quickly identify the optimal operating conditions and increase the level of process understanding.
The second part of the presentation will cover the construction and optimization of photo-bioreactors for carrying out light-driven biotransformations in recombinant cyanobacteria [2]. In particular, the stereoselective reduction of 2-methyl maleimide was investigated via a design-of-experiments approach.
Lastly, the combination of photo- and biocatalysis will be presented for a multistep flow process including an a-CF3-substituted ketone production in a self-made photoreactor, followed by an enzymatic ketoreduction catalyzed by an ADH-Lica (alcohol dehydrogenase) enzyme to obtain chiral trifluoromethylated alcohols.
Overall, our approaches successfully bridge well-established technologies in chemical engineering (such as additive manufacturing, process automation and optimization) with biotechnology (e.g. enzyme immobilization) and continuous flow to design more sustainable synthetic routes for fine chemicals and APIs.
[1] A. Valotta, M. C. Maier, S. Soritz, M. Pauritsch, M. Koenig, D. Brouczek, M. Schwentenwein, H. Gruber-Woelfler, J Flow Chem 2021, 11, 675–689
[2] A. Valotta, L. Malihan-Yap, K. Hinteregger, R. Kourist, H. Gruber-Woelfler, ChemSusChem. 2022, 15, e202201468
18:30
26 March 2024
Coolsingel Room
Rajat Pandey, Postdoctoral Fellow, Nelson Mandela University, South Africa
Flow Enabled Synthesis of Multiresistant Drug Clofazimine
Drug resistance to tuberculosis is still one of the significant challenges worldwide. Clofazimine, which belongs to the riminophenazine (anti-biotic) class, is still one of the active drugs that are efficient against drug resistance M. Tuberculosis. Apart from this, it is also a WHO-approved drug for the treatment of leprosy (Hansen's Disease) and, at present, is under phase 2 clinical trial for its activity against the SARS-CoV-2 virus. Owing to its vast importance in clinical research, we have developed a continuous-flow mediated synthesis of clofazimine using readily available p-chloroaniline and 1-fluro-2-nitrobenzene. The target drug molecule was obtained from four consecutive chemical transformations with nominal reaction time and improved purity and yields when compared to the batch process. Moreover, the first two steps were also successfully telescoped under optimized reaction conditions.