
Lipid Nanoparticles (LNPs) Asia/Pacific 2026
Date: Tuesday, October 13, 2026 - Wednesday, October 14, 2026
Location: Nikko Narita/Tokyo-Narita, Japan
Confirmed Speakers

Defang Ouyang, Associate Professor, University of Macau

Masatoshi Maeki, Associate Professor, Hokkaido University

Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California

Yusuke Sato, Associate Professor, Faculty of Pharmaceutical Sciences, Hokkaido University

Jiong-Wei Wang, Assistant Professor, Yong Loo Lin School of Medicine, National University of Singapore

Nan Zhang, Associate Professor, University College Dublin -- Conference Chairperson

Sven Kreutel, CEO, Particle Metrix, Inc.

Yuzuru Ito, Professor, Institute of Life and Environmental Sciences, University of Tsukuba

Marco Monopoli, RCSI University of Medicine and Health Sciences

Nhiem Tran, Senior Lecturer and Deputy Head of Department of Applied Chemistry and Environmental Science, RMIT University

Yi Yan Yang, Distinguished Principal Scientist, Agency for Science, Technology and Research (A*STAR)
Overview of the Conference
SelectBIO Lipid Nanoparticles (LNPs) Asia/Pacific 2026 Conference will be held October 13-14, 2026 at the Hotel Nikko Narita, right at Tokyo-Narita, Japan.
SelectBIO is honored to welcome Professor Nan Zhang, Associate Professor, University College Dublin, Ireland as the Conference Chairperson.
This conference is designed to bring forth the most up-to-date scientific and commercial trends in the LNPs space with emphasis on technology developments, commercial activities and broader applications of LNPs in the life sciences arena.
The successful deployment of LNPs in the SARS-Covid-19 virus vaccine has driven the interest in LNPs as a broader and scalable platform for delivery of cargo to cells and tissues in vivo.
This conference track is co-located and held concurrently with the POC and Rapid Diagnostics 2026 Conference Track -- all participants receive full access to all tracks for maximal scientific exchange and networking opportunities across disciplines.
The venue is right at Tokyo-Narita airport providing connections from around the world for exceedingly easy access to the conference.
Call for Abstracts for Oral Presentation or Poster
Agenda Topics Covered at this Conference
You can also present your research in an oral presentation or poster while attending the meeting. Submit an abstract for consideration under the Submissions tab of this conference website
Oral Presentation Abstract Submission Deadline: February 28, 2026
Poster Abstract Submission Deadline: October 1, 2026
Lipid Nanoparticles (LNPs) -- Production Approaches
Challenges & Opportunities in LNPs Space
Manufacture of Nanomedicines
Nanodelivery via LNPs
Extracellular Vesicles (EVs) and Lipid Nanoparticles (LNPs)
Emerging Application Areas for LNPs
Sponsorship and Exhibition Opportunities
Delegate Registrations for the Conference
Please register for the conference via online registration.
Any questions or assistance during registration, please e-mail us at: Contact SelectBIO
Gold Sponsors
Exhibitors
Sponsorship and Exhibition Opportunities
If you require any information about exhibiting or sponsoring at one of our events please contact Jeff Fan using the information below:
Jeff Fan
Exhibition Manager - SelectBIO Conferences
Why Sponsor-Exhibit at a SelectBIO Conference?
Specialists: SelectBIO doesn't organize conferences in shipping, accountancy, textiles etc. – just life sciences. Many of our staff have bioscience qualifications and many years of experience. So, we speak your language and understand your needs.
Superior Customer Service: Our sales team will take care of you with specialist advice and customized packages.
We don’t forget you after you sign on the bottom line either as our customer service dept. will alert you to all the things you need to think about up to and during the event itself.
Lipid Nanoparticles (LNPs) Asia/Pacific 2026 Conference Venue
SelectBIO is delighted to host Lipid Nanoparticles (LNPs) Asia/Pacific 2026 Conference at the following venue right at Tokyo-Narita Airport:
Hotel Nikko Narita
500 Tokko Narita-shi
Chiba 286-0106
Japan
Telephone: +81-476-32-0032
The Hotel Nikko Narita is very easily accessible from international destinations via Tokyo Narita International Airport (Airport Code: NRT).
The hotel can be accessed easily from Narita International Airport via a complimentary bus, usually around 10-15 minutes to and from the airport, depending on terminal chosen.
Distance-wise airport to the hotel is approximately 3 kilometers (1.8 miles).
If you are arriving to Narita Terminal 1, the shuttle to the hotel stops at bus stop # 16.
If you are arriving to Narita Terminal 2, the shuttle to the hotel stops at bus stop # 33.
Guests can make hotel bookings as well as see the different room types on the hotel website -- link below:




For any questions with the venue or logistics matters, please kindly contact SelectBIO Conferenes:
Jeff Fan
Events Manager, SelectBIO Conferences
E-mail: Jeff@selectbioconferences.com
SelectBIO has NOT authorized ANY third party company to assist in hotel bookings or any bookings or reservations for this conference. Please do NOT do business with any third party companies. If in doubt, please contact Jeff Fan immediately to clarify.
Register to this conference and also enjoy the following co-located events at no extra charge.
Training Courses
If you would like to submit a proposal for an oral or poster presentation at this meeting, please fill out the form below required for your submission.
Successful applicants will be provided with all necessary information.
Abstract Content:
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Written in English
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Written in the third person
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Include title, name(s) and affiliation(s) of the authors
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Between 100 - 200 words
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Suitable for direct publication in the proceedings pack and on the website
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Related to the subject of the conference
Agenda Topics
Lipid Nanoparticles (LNPs) -- Production Approaches
Challenges & Opportunities in LNPs Space
Manufacture of Nanomedicines
Nanodelivery via LNPs
Extracellular Vesicles (EVs) and Lipid Nanoparticles (LNPs)
Emerging Application Areas for LNPs
Copyrights
The presenting author/person who submitted the abstract assumes full responsibility of the content of the abstract and we assume that all co-authors are aware of this content. Please note that your biography, summary and abstract may be used on this website and conference materials.
Defang Ouyang, Associate Professor, University of Macau

Defang Ouyang Biographical Sketch
Prof. Ouyang has a multidisciplinary background in pharmaceutics & computer modelling, with experience in academia and industry. He obtained his bachelor (2000) and master (2005) in pharmaceutics from Shenyang Pharmaceutical University, China. He completed his PhD in pharmacy at The University of Queensland, Australia, in 2010 and progressed directly to his faculty position (Lecturer in Pharmaceutics, PI) at Aston University (UK). From the end of 2014, he moved to the University of Macau.
Since 2011, he has pioneered the integration of multi-scale modeling, artificial intelligence and big data techniques in the field of drug delivery – “computational pharmaceutics“. He has published 2 books, 5 book chapters and over 150 refereed SCI journal papers, along with more than 150 invited talks. He held over 10 approved patents, which had been used in medicinal products. He edited the first book in this research domain <Exploring Computational Pharmaceutics – AI and Modeling in Pharma 4.0> (Wiley, 1st Edition in 2015 & 2nd edition in 2024). He has developed the crucial “Rule of 5” for effective AI drug delivery models and successfully built the first global artificial intelligence (AI)-based formulation platform “FormulationAI” (https://formulationai.computpharm.org/).
He serves as the associate editor of <Drug Delivery and Translational Research>, the editorial board or scientific advisor of <Asian Journal of Pharmaceutical Sciences>, <Pharmaceutical Research>, and <Journal of Pharmaceutical Sciences>. He successfully trained 6 PhD and over 30 master students. He has been recognized as “World’s Top 2% Scientists” from 2020 to 2024.
His research focused on computational pharmaceutics, including:
Artificial intelligence (AI) in drug delivery: to develop advanced machine learning algorithms for drug delivery systems;
Multi-scale modeling in drug formulations: to integrate quantum mechanics (QM), molecular dynamics (MD) and physiologically based pharmacokinetic (PBPK) modeling into pharmaceutical formulations;
Pharmacoinformatics: big data analysis of pharmaceutical information from the literature, patent, clinical trial and marketed products.
Jiong-Wei Wang, Assistant Professor, Yong Loo Lin School of Medicine, National University of Singapore

Jiong-Wei Wang Biographical Sketch
Jiong-Wei Wang is an Assistant Professor at the Yong Loo Lin School of Medicine, National University of Singapore (NUS). He obtained his PhD in Medicine in 2013 from Leiden University Medical Center and completed postdoctoral training at University Medical Center Utrecht and NUS. His research focuses on cardiovascular immunology, extracellular vesicles, and nanomedicine-based drug delivery for cardiometabolic diseases, leveraging diverse animal models for preclinical investigation. Dr Wang has published over 110 peer-reviewed articles and has received multiple honors, including the Wong Hock Boon Society–Singapore Medical Association (SMA) Charity Fund Outstanding Mentor Award (2019), the NUS Yong Loo Lin School of Medicine Young Researcher of the Year Award (2023), and the Research Excellence Award (2026).
Marco Monopoli, RCSI University of Medicine and Health Sciences

Marco Monopoli Biographical Sketch
Dr Marco Monopoli is a Senior (tenured) Lecturer in the RCSI Chemistry Department and where he established the BioNano Research lab, a multi-disciplinary centre focused on obtaining a complete understanding of the mechanisms of interaction between nanomaterials and living systems essential for nanomedicine, nanotoxicology applications and evaluating their environmental impact. Dr Monopoli's studies have been focused on revealing the forces that govern bio-nano interactions and understanding the biological implications of the biomolecular corona, with a particular interest in the glycans.
Masatoshi Maeki, Professor, Hokkaido University

Masatoshi Maeki Biographical Sketch
Masatoshi Maeki is a Professor in the Division of Applied Chemistry at the Faculty of Engineering, Hokkaido University. He received his Ph.D. degree in 2014 from Kyushu University. After graduation, he worked as a Research Fellow of the Japan Society for the Promotion of Science (JSPS) at Hokkaido University. He joined the Faculty of Engineering at Hokkaido University as an Assistant Professor in 2015, was promoted to Associate Professor in 2021, and became a Professor in 2026. His research focuses on the development of microfluidic devices for applications in drug delivery systems and biomolecular analysis. He has received several awards, including the Minister of Education, Culture, Sports, Science and Technology (MEXT) Prize for Young Scientists in the field of science and technology in 2024. He also received the Hokkaido Science and Technology Encouragement Award in 2023, the Japan Society for Analytical Chemistry Award for Young Researcher’s in 2016, and the Young Innovator Award on Chemistry and Micro-Nano Systems (CHEMINAS Young Innovator Award) in 2015.
Nan Zhang, Associate Professor, University College Dublin -- Conference Chairperson

Nan Zhang Biographical Sketch
Dr Nan Zhang is an Associate Professor in Manufacturing and Design at the School of Mechanical and Materials Engineering of University College Dublin (UCD) in Ireland. His research covers polymer micro/nano manufacturing, precision manufacturing of plastic microfluidic chips, microfluidic systems for synthesising genetic nanomedicine and molecular diagnostics, manufacturing functional micro/nano structured surfaces, and atomic and close-to-atomic-scale manufacturing. He has been founded by H2020 MSCA ITN Grant as a consortium coordinator, Science Foundation Ireland, Enterprise Ireland-Commercialization Funding, Irish Research Council etc. He has published more than 60 peer-reviewed journal papers in Materials Today, Nano Letters and the International Journal of Machine Tool and Manufacture. He was the chair of the 6th and 8th international conferences on polymer replication on the nanoscale (PRN2019, PRN2022). He is the associate editor of the journal “Frontier-Lab on Chip Technology” and a Council member of the Microfluidic Association. His research has generated several patents which have been commercialized or are in the process of being commercialized. He has received the University Research Impact award in 2022, the Year of Invention Award 2024, and has been highlighted as a Rising Star Fellow by UCD.
Nhiem Tran, Senior Lecturer and Deputy Head of Department of Applied Chemistry and Environmental Science, RMIT University

Nhiem Tran Biographical Sketch
Nhiem Tran, Senior Lecturer and Deputy Head of Department of Applied Chemistry and Environmental Science, RMIT University
Dr. Nhiem Tran is Deputy Head of International, Engagement, and Outreach and a tenured Senior Lecturer in the Department of Applied Chemistry and Environmental Science at RMIT University, Australia. He obtained his PhD in Physics from Brown University, USA, in 2012 and has been awarded several prestigious fellowships, including the CSIRO John Stocker Postdoctoral Fellowship and the RMIT Vice-Chancellor's Research Fellowship.
Dr. Tran has established an internationally recognised research program in nanomedicine, biomaterials, and lipid nanoparticle engineering. His research has advanced the understanding of how lipid self-assembly and nanostructure govern drug and RNA delivery, cellular interactions, and biological performance, underpinning the development of smart, stimuli-responsive nanocarriers and infection-resistant biomaterials. He has published more than 80 peer-reviewed articles and received the 2025 RMIT STEM College Deputy Vice Chancellor Impact Research and Innovation Award.
Beyond research, Dr. Tran is committed to advancing the scientific community through leadership and service. He serves on the Board of Directors of the Australasian Colloid and Interface Society (ACIS) and is an Editorial Board Member of Discover Nano, contributing to the promotion of research excellence and collaboration in nanoscience and biomaterials.
Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California

Noah Malmstadt Biographical Sketch
Noah Malmstadt is Professor at the University of Southern California. He received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. Malmstadt is the recipient of a 2012 Office of Naval Research Young Investigator award. His research focuses on microfluidic strategies to facilitate material fabrication and biophysical analysis. He has pioneered the integration of ionic liquids as solvents in droplet microreactors and the application of microfluidic systems to synthesizing biomimetic cell membranes. Microfluidic analytical techniques he has developed include methods for measuring the permeability of cell membranes to druglike molecules and techniques for measuring ionic currents through membrane proteins.
Sven Kreutel, CEO, Particle Metrix, Inc.

Sven Kreutel Biographical Sketch
Sven Kreutel studied biology at the University of Hohenheim in Stuttgart, Germany. After his graduation in biology, he received his PhD in microbiology and protein biochemistry at the University of Hohenheim under Prof. Dr. Andreas Kuhn and Dr. Dorothee Kiefer working on the light sensing and signal transduction in photosynthetic bacteria. Since then he worked in different sales and sales manager positions within the life science industry from clinical research over biology to nanoparticle sciences. In 2021 he was appointed as CEO of the American subsidiary of Particle Metrix.
Yi Yan Yang, Distinguished Principal Scientist, Agency for Science, Technology and Research (A*STAR)

Yi Yan Yang Biographical Sketch
Yi Yan YANG is a Distinguished Principal Scientist in Bioprocess Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Republic of Singapore. She obtained her Ph.D. degree from Tsinghua University (China) in 1990. She has more than 300 publications in peer-reviewed journals including Nat. Mater., Nat. Nanotech., Nat. Chem., Nat. Commun. and Nat. Biomedical Eng., and more than 70 primary patents granted (5 patents were licensed to startup companies). She has received many invitations to hold lectures and seminars in Singapore and overseas. She was 2022 and 2025 highly cited researcher recognized by Clarivate™. She was elected to Fellow, the Academy of Engineering, Singapore in July 2021. She was recognized in Stanford’s Top 2% Scientists Worldwide in 2021-2025. In January 2016, she was elected to Fellow, the American Institute for Medical and Biological Engineering (AIMBE). Her work on antimicrobial polymers was named Scientific American’s “Top 10 World Changing Ideas” in 2011. She is an Associate Editor for Nanomedicine: Nanotechnology, Biology and Medicine, an International Advisory Board Member for Advanced Healthcare Materials, and an Editorial Board Member for Drug Delivery. Her current research is mainly focused on targeted delivery of mRNA for vaccine, cancer therapy, infection and other diseases.
Yusuke Sato, Associate Professor, Faculty of Pharmaceutical Sciences, Hokkaido University

Yusuke Sato Biographical Sketch
Yusuke Sato, Ph.D. is an Associate Professor at the Faculty of Pharmaceutical Sciences, Hokkaido University, Japan. He previously served as a JSPS Research Fellow (DC1) during his doctoral studies and later as an Assistant Professor, where he established his research program in pharmaceutical sciences. Dr. Sato’s research focuses on the molecular design of ionizable and zwitterionic lipids and the development of lipid nanoparticles (LNPs) for in vivo delivery of macromolecular therapeutics, including siRNA, mRNA, and Cas9 ribonucleoprotein (RNP) complexes. His work integrates lipid chemistry, formulation science, and biological evaluation to advance next-generation nucleic acid and genome-editing therapeutics.
Yuzuru Ito, Professor, Institute of Life and Environmental Sciences, University of Tsukuba

Yuzuru Ito Biographical Sketch
Prof. Yuzuru Ito specializes in stem cell biology and biotechnology, focusing on the research and development of drug discovery support platforms (e.g., MPS). He also serves as an expert for ISO/TC 276, contributing particularly to standardization related to analytical methods.
08:00
13 October 2026
Conference Registration
Participants Check-In
Conference Registration, Materials Pick-Up, Coffee and Networking
08:30
13 October 2026
Please view Agenda for Conference Day 1 (October 13, 2026) in the Microfluidics Track of this Conference
**All Participants will Spend Day 1 of the Conference in the Microfluidics, POC-Dx, Organ-on-Chip, and EV Track**
**Day 2 of the Conference is Primarily Focused on LNPs with a Late Afternoon EV Session**
08:30
14 October 2026
Exhibits -- Foyer
Morning Coffee and Networking in the Exhibit Hall
09:00
14 October 2026
Fuji Room

Nan Zhang, Associate Professor, University College Dublin
Welcome and Introduction by Conference Chairperson + An Overview of LNPs
09:30
14 October 2026
Fuji Room

Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California
A Deep Dive into LNPs
10:00
14 October 2026
Fuji Room

Nhiem Tran, Senior Lecturer and Deputy Head of Department of Applied Chemistry and Environmental Science, RMIT University, Australia
Lipid Self-Assembly: From Nanostructure to Therapeutic Function
Lipid nanoparticles (LNPs) have emerged as versatile carriers for drugs, nucleic acids, and mRNA therapeutics. Among them, lyotropic liquid crystalline nanoparticles exhibit complex internal mesophase structures, including inverse hexagonal and bicontinuous cubic phases, that critically influence cargo encapsulation, release kinetics, cellular interactions, and in vivo biodistribution. However, achieving precise control over lipid self-assembly remains a major challenge, particularly in multicomponent formulations. This presentation will highlight strategies to understand and control lipid self-assembly using synchrotron small-angle X-ray scattering (SAXS) to elucidate structure–property relationships. By tailoring internal nanostructures, we have developed lipid nanoparticles with tunable biological performance and targeted delivery characteristics. The presentation will also describe the design of pH-responsive "smart" LNPs containing novel ionisable lipids that undergo structural transitions in acidic environments, enabling enhanced drug release at tumour and infection sites. Applications of these responsive nanocarriers for delivering anticancer and antimicrobial agents, as well as RNA therapeutics for chronic kidney disease, will be discussed, demonstrating how controlling lipid self-assembly enables next-generation nanomedicines.
10:30
14 October 2026
Exhibits -- Foyer
Mid-Morning Coffee Break -- Network with Colleagues and Engage with the Exhibitors
11:00
14 October 2026
Fuji Room

Masatoshi Maeki, Professor, Hokkaido University, Japan
Development of a Cell-Free Virus-like Particle Production Method Using Microfluidic Devices
mRNA-loaded lipid nanoparticles (LNPs) have been used in practice as COVID-19 vaccines, and their application to cancer vaccines is now advancing. Recently, modification of the LNP surface with proteins or antibodies has attracted considerable attention, as such modification is expected to enable cell- and tissue-specific delivery and to enhance the induction of neutralizing antibodies. Conventional surface modification, however, requires laborious chemical processes. In this presentation, I will introduce a cell-free, one-step microfluidic method for producing virus-like and protein-decorated lipid-based nanoparticles. In addition, conventional microfluidic LNP production has employed the ethanol dilution method. I will also introduce an aqueous, organic solvent-free method for LNP production.
11:30
14 October 2026
Fuji Room

Yusuke Sato, Associate Professor, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
Molecular Design of Functional Lipids for Macromolecular Delivery in vivo
Lipid nanoparticles (LNPs) are drug delivery carriers capable of encapsulating macromolecules such as functional nucleic acids, including mRNA, as well as proteins, and delivering them to target tissues and cells. LNP-based technologies have already been translated into clinical practice, most notably in COVID-19 mRNA vaccines. At present, their application is rapidly expanding to a wide range of therapeutic areas, including vaccines, protein replacement therapy, regenerative medicine, and genome-editing therapies. My research has focused on enhancing and diversifying the functionality of LNP formulations through the rational molecular design of original functional lipids. In this presentation, I will introduce insights obtained to date and discuss how molecular design of functional lipids contributes to the development of advanced LNP formulations.
12:00
14 October 2026
Fuji Room

Yi Yan Yang, Distinguished Principal Scientist, Agency for Science, Technology and Research (A*STAR), Singapore
PEG-free Lipid Nanoparticles for Targeted mRNA Delivery
Current lipid nanoparticles (LNPs) used for mRNA delivery lack extrahepatic cell-targeting capabilities due to the inclusion of PEGylated lipid (PEG-lipid) in their formulations. PEG-lipid tends to dissociate from LNPs upon systemic administration, leading to ApoE protein adsorption and subsequent accumulation in the liver. Additionally, pre-existing anti-PEG antibodies in many individuals can accelerate blood clearance of PEGylated LNPs, potentially reducing mRNA efficacy. Targeting antigen-presenting cells (APCs) such as dendritic cells and macrophages could enhance immune responses and improve vaccination outcomes. This talk is focused on strategies of mitigating PEG immunogenicity and enhancing targeted delivery of mRNA vaccines towards antigen-presenting cells.
12:30
14 October 2026
Exhibits -- Foyer
Networking Lunch -- Japanese Bento -- Meet with Exhibitors and Engage with Colleagues Over Lunch
13:30
14 October 2026
Fuji Room

Jiong-Wei Wang, Assistant Professor, Yong Loo Lin School of Medicine, National University of Singapore
LNP-based Therapeutic Strategies for Cardiometabolic Diseases
Lipid nanoparticles (LNPs) have been extensively explored for nucleic acid delivery across diverse therapeutic areas, highlighted by their clinical success in RNA-based medicines and vaccines. Beyond currently approved formulations, a growing array of engineered LNP platforms is being developed to impart enhanced functionality, targeting capability, and therapeutic efficacy. Our research focuses on the application of LNP-mediated RNA delivery for cardiometabolic diseases, including fatty liver disease and cardiovascular disease. In this presentation, I will highlight our recent studies in LNP design and their therapeutic modulation of cardiometabolic pathologies, emphasizing translational strategies and preclinical outcomes.
14:00
14 October 2026
Fuji Room

Yuzuru Ito, Professor, Institute of Life and Environmental Sciences, University of Tsukuba, Japan
Development of MPS and its Application in Drug Discovery - Affinity with LNP Development
As one of the NAMs, MPS—an in vitro complex model integrating cells and devices—is expected to be utilized in the drug development process. By combining organ cells with devices, it becomes possible to recreate complex microenvironments, enabling the reproduction of the dynamics of various modalities within living organisms.
This presentation introduces case studies of MPS application development conducted under a Japanese national project and discusses their affinity with LNP research and development.
14:30
14 October 2026
Fuji Room

Defang Ouyang, Associate Professor, University of Macau
Artificial Intelligence-driven Rational Design of Ionizable Lipids for mRNA Delivery
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial intelligence (AI) and virtual screening to facilitate the rational design of ionizable lipids by predicting two key properties of LNPs, apparent pKa and mRNA delivery efficiency. Nearly 20 million ionizable lipids were evaluated through two iterations of AI-driven generation and screening, yielding three and six new molecules, respectively. In mouse test validation, one lipid from the initial iteration, featuring a benzene ring, demonstrated performance comparable to the control DLin-MC3-DMA (MC3). Notably, all six lipids from the second iteration equaled or outperformed MC3, with one exhibiting efficacy akin to a superior control lipid SM-102. Furthermore, the AI model is interpretable in structure-activity relationships.
15:00
14 October 2026
Fuji Room
Keynote Presentation

Marco Monopoli, RCSI University of Medicine and Health Sciences, Republic of Ireland
Understanding the Nanomaterial Interaction with Biomolecules, A Journey from Safety to Applications in Nanomedicine
For nanomedicine and nanosafety, there is a growing desire for a rational basis within which to understand nanoparticle-cell and organ-level interactions. Nanoparticles in biological fluids (blood, or otherwise) generically associate with a range of biopolymers, especially proteins, organised into the ‘protein corona’ which is continuously exchanging with the proteins in the environment. In some cases, the residence times of proteins in the corona are sufficiently long that they confer an effective biological identity onto the nanoparticle. The transport and fate of nanoparticles (from intracellular trafficking to clearance pathways) likely reflect the corona, rather than the nanomaterial itself.
It is now clear that these interactions lead to dramatic surface changes and a new identity of the NP in biological fluid and the corona can induce unpredictable immunological responses and can hamper their therapeutic efficacy. The protein corona is derived from proteins in biological fluids, many of which are glycosylated. We have now shown that the biomolecular corona has a strong glycosylation component that is biologically active, and this class of biomolecules plays a role in the NP colloidal stability, biological fate, and, if controlled, can offer new opportunities in nanomedicine.
15:30
14 October 2026
Exhibits -- Foyer
Late-Afternoon Coffee and Tea Break and Networking in the Exhibit Foyer
16:00
14 October 2026
Fuji Room

Juntaro Matsuzaki, Professor, Division of Interdisciplinary Genetics and Nanomedicine, Research Center for Drug Discovery, Keio University Faculty of Pharmacy, Japan
Multifaceted Roles of Extracellular RNAs: From Cancer Biomarkers to Bacterial EV Function
This presentation highlights the clinical and functional significance of extracellular RNAs (exRNAs) in oncology and microbiology. The first half addresses the utility of serum microRNAs (miRNAs) as robust biomarkers for early-stage cancer detection and as potential therapeutic targets, drawing on comprehensive expression profiling from a Japanese national project. Utilizing advanced bioinformatics, we demonstrated the high diagnostic performance of liquid biopsy approaches in solid cancers. Expanding beyond mammalian systems, the second half introduces our latest findings on bacterial extracellular vesicle RNAs (bacterial EV-RNAs). Emerging evidence reveals that these microbial exRNAs possess distinct functional potentials, actively mediating intercellular and cross-kingdom communication. By bridging the translational microRNA biomarkers with the frontier of bacterial EV-RNA biology, this talk discusses the multi-faceted roles of exRNAs and outlines future directions for novel diagnostics and therapeutics.
16:30
14 October 2026
Fuji Room

Nao Nishida-Aoki, Associate Professor, Global Center for Science and Engineering, Faculty of Science and Engineering, Waseda University, Japan
Mapping Cancer Extracellular Vesicle Delivery Networks in Metastatic Tissue Microenvironments
Cancer-derived extracellular vesicles (EVs) contribute to metastatic niche formation, but how EVs are transferred and interpreted within intact tissue environments remains unclear. To address this, we established organotypic ex vivo models of breast cancer metastasis using mouse brain and lung tissue slice cultures, combined with HaloTag-based EV labeling. This platform enabled direct visualization of EV secretion and transfer within preserved tissue architecture. We observed heterogeneous EV secretion and distribution among cancer cells, as well as organ-dependent EV accumulation patterns within metastatic tissues. Spatial transcriptomic analysis further suggested that EV-enriched regions are associated with localized host-tissue responses. Together, these findings suggest that cancer EVs form tissue-specific delivery networks that may contribute to early metastatic niche remodeling. This approach provides a framework to link EV dynamics with spatial tissue responses during metastatic colonization.
17:00
14 October 2026
Fuji Room

Shannon Callen, Research Coordinator, University of Nebraska Medical Center, United States of America
From Mechanisms to Relevance: How Do We Determine When Extracellular Vesicles Matter Biologically?
The extracellular vesicle (EV) field has made remarkable progress in identifying cargo molecules, signaling pathways, and potential biomarkers. Yet important questions remain regarding physiological relevance, functional significance, and how EV-associated mechanisms should be interpreted within complex biological systems. This presentation will examine the assumptions and conceptual frameworks commonly used in EV research and discuss how they influence conclusions about causality, biological contribution, and translational potential. Drawing on concepts from systems biology, the talk will explore how biological context, organizational principles, and cellular constraints may shape EV production and function beyond individual cargo molecules and signaling mechanisms. By focusing on the distinction between demonstrating mechanism and establishing biological relevance, the presentation aims to stimulate discussion on how the field can bridge mechanistic discoveries with meaningful biological and translational insight and move toward a more predictive understanding of EV biology.



