
Emerging Technologies and Paradigms for In Vitro Dx Europe 2024
Date: Monday, 18 March 2024 - Tuesday, 19 March 2024
Location: Rotterdam, The Netherlands
Confirmed Speakers

Adam Hall, Associate Professor of Biomedical Engineering, Wake Forest School of Medicine

David Wong, Felix and Mildred Yip Endowed Chair in Dentistry; Director for UCLA Center for Oral/Head & Neck Oncology Research, University of California-Los Angeles

Jaebum Choo, Professor, Chung-Ang University

Rebecca Whelan, Associate Professor of Chemistry, University of Kansas

Yoon-Kyoung Cho, Professor, Biomedical Engineering, Ulsan National Institute of Science & Technology; Group leader, IBS; FRSC, Fellow of Royal Society of Chemistry

Andrew Godwin, Professor and Division Director, Genomic Diagnostics, Founding Director, Kansas Institute for Precision Medicine, Deputy Director, KU Cancer Center, University of Kansas Medical Center

Erik Vollebregt, Partner, Axon Lawyers

Martyn Boutelle, Professor of Biomedical Sensors Engineering, Imperial College London

Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-Scale System for Precision Medicine, The University of Kansas -- Conference Chairperson

Daniel Chiu, A. Bruce Montgomery Professor of Chemistry, University of Washington

Hyungsoon Im, Associate Professor, Center for Systems Biology, Mass General Hospital (MGH)/Harvard Medical School

Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame

Tony Hu, Professor and Weatherhead Presidential Chair, Tulane University School of Medicine
Overview of the Conference
SelectBIO is pleased to welcome you to Emerging Technologies and Paradigms for In Vitro Diagnostics Europe 2024 to be held 18-19 March 2024 at the Marriott Rotterdam -- Rotterdam, The Netherlands.
The goal of this conference is to provide a deep dive into the current technical landscape of technologies and approaches for building novel in vitro diagnostics including rapid diagnostics delivered at the point-of-need, point-of-care.
Additionally, we bring together the ecosystem of legal and regulatory framework that together with the technologies being developed sets forth the stage for commercial successes or failures.
Companies are invited to participate and present their technologies, and their offerings to this marketplace.
The conference includes invited presentations, sponsored presentations by companies as well as a co-located exhibit hall for companies to commercially-engage with the conference participants.
There are extensive opportunities for networking and SelectBIO Conferences includes breakfasts, lunches and networking receptions as a means to bring together the participants and foster networking and engagement.
The location of the Marriott Rotterdam is ideal -- right across from Rotterdam Centraal offering fast connections to Amsterdam-Schiphol Airport, Antwerp, Brussels and Paris and the Eurostar to London.
SelectBIO is honoured that Professor Dr. Steve Soper, key opinion leader in the field, is Conference Chairperson.
Call for Posters
You can also present your research on a poster while attending the meeting. Submit an abstract for consideration now!
Poster Submission Deadline: 4 March 2024
Agenda Topics
- • Circulating Biomarkers: cfDNA, RNA, EVs, Others
• Developed Diagnostics Tests -- Cancer Mutation Testing, and Diseases Beyond Cancer Such as CVD and CNS Diseases
• Emerging Point-of-Care Diagnostics (POC) Technologies
• Emerging Technologies for Developing Dx: Surface-Enhanced Raman, Plasmonics, and Others
• Liquid Biopsy in 2024 -- Status Update
• Screening for Early Disease Detection
Sponsorship and Exhibition Opportunities
Jeff Fan
Exhibition Manager - SelectBIO
E-mail: Jeff@selectbioconferences.com
3 for 2 Offer on Delegate Registrations
SelectBIO are offering 3 Delegate Registrations for the price of 2 on all delegate passes. To take advantage of this offer, please contact us by email, phone or click the Contact Us button below. Looking for more than 3 Delegate Passes? Contact us for more information on our special rates for large groups.
Any questions or assistance during registration, please call us at: +1 (510) 857-4865 or e-mail us at: Contact SelectBIO
Gold Sponsors
Exhibitors
If you require any information about exhibiting or sponsoring at one of our events please contact Jeff Fan using the information below:
Jeff Fan
Exhibition Manager - SelectBIO
Email: Jeff@selectbioconferences.com
Why Exhibit at a SelectBIO Conference?
Specialists: SelectBIO doesn't organize conferences in shipping, accountancy, textiles etc. – just drug discovery and the life sciences. Many of our staff have bioscience qualifications and many years of experience. So, we speak your language and understand your needs.
Superior Customer Service: Our sales team will take care of you with specialist advice and customized packages. We don’t forget you after you sign on the bottom line either as our customer service dept. will alert you to all the things you need to think about up to and during the event itself.
Emerging Technologies & Paradigms for In Vitro Dx Europe 2024 Venue
SelectBIO is delighted to host the Emerging Technologies & Paradigms for In Vitro Dx Europe 2024 Conference at the Marriott Rotterdam, Rotterdam, The Netherlands.
Rotterdam Marriott
Weena 686, 3012 CN Rotterdam
The Netherlands
The Rotterdam Marriott is right across from Rotterdam Centraal Station with fast connections across The Netherlands, to Amsterdam Schiphol Airport (airport code: AMS), and destinations across Europe and across the world.
From Rotterdam Centraal you can take a high-speed train to Belgium and then onto Paris.
All conference sessions, exhibition as well as networking reception will be held at The Marriott Rotterdam.
SelectBIO has negotiated discounted pricing for conference attendees at the Rotterdam Marriott Hotel:
Single Room: 209 € per night which includes breakfast, WiFi, and the VAT but excludes 6.5% city tax.
To make your Hotel Reservations by Telephone:
Please call +31 10 430 2222 and ask for the Reservations Department. The group name that you should refer to for this rate is “Select Biosciences”
To make your Hotel Reservations Online:




For any hotel reservation-related issues, or if you need any help with hotel bookings, please contact:
Jeff Fan
Events Manager, SelectBIO
E-mail: Jeff@selectbioconferences.com
SelectBIO has NOT authorized ANY third party company to assist in hotel bookings or reservations for the conference. Please do NOT do business with any third party companies. If in doubt, please contact Jeff Fan immediately to clarify.
Register to this conference and also enjoy the following co-located events at no extra charge.
Training Courses
If you would like to submit a proposal for an oral or poster presentation at this meeting, please fill out the form below required for your submission.
Successful applicants will be provided with all necessary information.
Abstract Content:
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Written in English
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Written in the third person
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Include title, name(s) and affiliation(s) of the authors
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Between 100 - 200 words
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Suitable for direct publication in the proceedings pack and on the website
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Related to the subject of the conference
Agenda Topics
- • Circulating Biomarkers: cfDNA, RNA, EVs, Others
• Developed Diagnostics Tests -- Cancer Mutation Testing, and Diseases Beyond Cancer Such as CVD and CNS Diseases
• Emerging Point-of-Care Diagnostics (POC) Technologies
• Emerging Technologies for Developing Dx: Surface-Enhanced Raman, Plasmonics, and Others
• Liquid Biopsy in 2024 -- Status Update
• Screening for Early Disease Detection
Copyrights
The presenting author/person who submitted the abstract assumes full responsibility of the content of the abstract and we assume that all co-authors are aware of this content. Please note that your biography, summary and abstract may be used on this website and conference materials.
Adam Hall, Associate Professor of Biomedical Engineering, Wake Forest School of Medicine

Adam Hall Biographical Sketch
Adam R. Hall received his training in physics and materials sciences at the University of North Carolina at Chapel Hill, where he was a NASA Graduate Student Research Program (GSRP) Fellow and received the Ross & Charlotte Johnson Family Dissertation Fellowship. He then spent three years as a postdoctoral researcher at Technische Universitat Delft in the Netherlands. From 2010-13, he was an Assistant Professor of Nanoscience at the Joint School of Nanoscience and Nanoengineering in Greensboro, NC, where he earned awards for both his research activities and teaching. He joined the faculty of the Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences in August of 2013 as an Assistant Professor in the Wake Forest School of Medicine. He was promoted to Associate Professor with tenure in 2021 and was appointed Assistant Director of Translational Research for the Atrium Wake Forest Comprehensive Cancer Center in 2023. Dr. Hall has published more than 50 journal articles, is an inventor on 5 patents, and his research has been supported by diverse agencies including the National Institutes of Health (NCI, NIGMS, NIBIB, and NHGRI), DoD, BARDA, 3M, and the North Carolina Biotechnology Center. His research focuses on translational applications of micro- and nanotechnologies.
Andrew Godwin, Professor and Division Director, Genomic Diagnostics, Founding Director, Kansas Institute for Precision Medicine, Deputy Director, KU Cancer Center, University of Kansas Medical Center

Andrew Godwin Biographical Sketch
Andrew K. Godwin, PhD, the Chancellors Distinguished Chair in Biomedical Sciences endowed Professor, is a leader in the field of translational research and precision medicine. A native of Lawrence, Kansas, Andy graduated with highest distinction from the University of Kansas with a bachelor’s degree in Cellular Biology. He obtained his PhD in Molecular Biology from the University of Pennsylvania while carrying out his thesis research at Fox Chase Cancer Center in Philadelphia. Andy holds the distinction of being the only graduate student at FCCC to become a senior member (full professor with tenure). While at FCCC he had the pleasure of learning from “giants” in their respective fields of science. He was appointed leader of the FCCC’s Cancer Center Support Grant Ovarian Cancer Program in 2008 and served as co-leader of the Women's Cancer Program from 2009 to 2010. He was also the director of both the Clinical Molecular Genetics/Pathology Laboratory and the Biosample Repository at FCCC since their inception in 1995 and 1999 respectively, until leaving FCCC.
Andy was recruited to KUMC as the Associate Director for Translational Research for the KU Cancer Center in October 2010 after 26 productive years at FCCC and his engaged participation contributions towards NCI designation in 2012/2017 and comprehensive designation in 2022, resulted in him being named the Deputy Director in 2013. He serves the director of Molecular Oncology at the KU Medical Center. In the latter position, he founded the Clinical Molecular Oncology Laboratory, a CLIA-certified, CAP-accredited molecular diagnostics laboratory, and heads KU’s institutional efforts in precision medicine. He was appointed the Division Director for Genomic Diagnostic for the KU Health System in 2020. He also founded the Center for Genetics Services and Health Equity, to address health disparities in our region and nationally. Andy holds secondary appointments as a Professor in the Department of Internal Medicine, and the Department of Microbiology, Molecular Genetics, and Immunology. He also leads the ovarian cancer research-working group, is a member of the Investigator Initiated Trial Steering Committee, serves as the Scientific Director for the Biomarker Discovery Laboratory, the Director of the KU Cancer Center’s Biospecimen Shared Resource, and the KU Medical Center’s Biospecimen Repository Core Facility. He was named the Vice Chair for the Breast Translational Medicine subcommittee of the Southwest Oncology Group in 2018 and was appointed to the National Cancer Institute’s NCTN Core Correlative Sciences Committee (NCTN-CCSC) in 2021.
Andy is the founding director of the Kansas Institute for Precision Medicine Centers of Biomedical Research Excellence (COBRE) (P20 GM130423). He was named a Kansas Bioscience Authority Eminent Scholar in 2010 and the University of Kansas School of Medicine Chancellor’s Distinguished Chair in Biomedical Sciences Endowed Professor in 2012. In 2014, Andy received the KUMC School of Medicine’s Achievement Award for the mentoring of post-doctorate students. Of his awards, he is most proud of being acknowledged for his years of mentoring. He has mentored over 150 trainees, including high school students, undergraduates, graduate students, postdoctoral associates/fellows, medical students/fellows, visiting scientists, and junior faculty during his academic career.
Brian Cunningham, Professor and Intel Alumni Endowed Chair, University of Illinois at Urbana-Champaign

Brian Cunningham Biographical Sketch
Prof. Cunningham has been a faculty member in the department of Electrical and Computer Engineering and the department Bioengineering at the University of Illinois at Urbana-Champaign since 2004, following a 15-year career in Industry. Prof. Cunningham’s technical focus is the utilization of photonics for biosensing in applications that include life science research, diagnostics, environmental monitoring, and pharmaceutical screening. He has over 90 issued US patents and over 200 peer reviewed journal publications. He is a Fellow of NAI, IEEE, Optica, RSC, AAAS, and AIMBE. He serves as the Director of the Center for Genomic Diagnostics at the Woese Institute for Genomic Biology, and as a Program Leader for the Cancer Center at Illinois on the topic of Cancer Measurement Technology and Data Science. In 2023, his technical contributions were recognized by Optica by the Michael S. Feld Biophotonics Award.
Daniel Chiu, A. Bruce Montgomery Professor of Chemistry, University of Washington

Daniel Chiu Biographical Sketch
Daniel T. Chiu is currently the A. Bruce Montgomery Professor Chemistry, Endowed Professor of Analytical Chemistry, and Professor of Bioengineering at the University of Washington. He is a member of the University of Washington’s Center for Nanotechnology, Neurobiology and Behavior Program, and the Cancer Consortium of the Fred Hutchinson Cancer Research Center. He has authored more than 180 publications and is the inventor on over 40 issued patents. Dr. Chiu obtained a B.A. in neurobiology and a B.S. in chemistry at the University of California, Berkeley in 1993, and a Ph.D. in chemistry from Stanford University in 1998.
David Wong, Felix and Mildred Yip Endowed Chair in Dentistry; Director for UCLA Center for Oral/Head & Neck Oncology Research, University of California-Los Angeles

David Wong Biographical Sketch
David T.W. Wong DMD, DMSc is Felix & Mildred Yip Endowed Professor, Associate Dean of Research and Director of the Oral/Head and Neck Oncology Research Center at UCLA. Dr. Wong is an active scientist in oral cancer and saliva diagnostics research. He has authored over 280 peer reviewed scientific publications. He is a fellow of the American Association for the Advancement of Sciences (AAAS), past member of the ADA Council of Scientific Affairs and the past president of American Association of Dental Research (AADR).
Erik Vollebregt, Partner, Axon Lawyers

Erik Vollebregt Biographical Sketch
Erik specializes in EU and national legal and regulatory issues relating to medical devices, including eHealth, mHealth, software and protection of personal data. He is an expert in life sciences regulation at EU and Dutch level, with a focus on contracts, regulatory litigation against competent authorities and M&A. Erik was initially trained as intellectual property and competition lawyer, starting his career at the Directorate-General for Competition of the European Commission. He subsequently gained experience in contentious matters, commercial contracts, and transactional work at three large international law firms. He actively contributes to law and policy development at national and EU level via membership of specialized committees at branch associations and the European Commission. Erik also works as arbitrator in medical devices related disputes and is regularly retained as expert witness in foreign litigation.
Hyungsoon Im, Associate Professor, Center for Systems Biology, Mass General Hospital (MGH)/Harvard Medical School

Hyungsoon Im Biographical Sketch
Dr. Hyungsoon Im is Associate Professor of Radiology at Harvard Medical School and Massachusetts General Hospital. His research aims to bridge engineering and medicine fields by developing next-generation diagnostic sensing technologies to better understand the makeup of human diseases and changes associated with disease progression and therapy. He also develops and applies artificial intelligence (AI) to multiomics data to improve data analysis accuracies and robustness. Dr. Im has been actively working with clinical investigators both in and outside of MGH to validate my technologies for clinical samples and apply them in clinical settings.
Jaebum Choo, Professor, Chung-Ang University

Jaebum Choo Biographical Sketch
Jaebum Choo is a Professor in the Department of Chemistry at Chung-Ang University in South Korea. He earned his Ph.D. from Texas A&M University in 1994. From 1995 to 2019, he served as a faculty member at Hanyang University. In 2015, he was appointed as a Baik Nam Distinguished Professor, acknowledging his outstanding academic accomplishments. In 2016, he served as the President of the Korea Biochip Society, and in 2020, he chaired the Analytical Chemistry Division of the Korean Chemical Society. Currently, Professor Choo holds the position of Vice-President for Research at Chung-Ang University and serves as the Director of the "Center for Nanophotonics-based Biomedical Diagnostics Research Center (ERC)," supported by the National Research Foundation of Korea. He is currently the associate editor of Analyst at the Royal Society of Chemistry and a member of the editorial board for ACS Sensors and Analytical Chemistry at the American Chemical Society. His ongoing research programs focus on developing highly sensitive optical nano-sensor systems for rapid and precise in vitro diagnostics of infectious diseases. Throughout his career, Professor Choo has delivered over 150 invited lectures in the USA, Europe, and Asia. He has published more than 300 research papers in peer-reviewed journals (with ~22,000 citations and an H-index of 76) and has contributed to eight book chapters.
Martyn Boutelle, Professor of Biomedical Sensors Engineering, Imperial College London

Martyn Boutelle Biographical Sketch
Martyn Boutelle is Professor of Biomedical Sensors Engineering in the Department of Bioengineering, Imperial College London, and Associate Provost for Estates Planning for Imperial College.
His research group is multidisciplinary comprising, bioengineers, scientists, and clinicians. He develops novel analytical science methods using microfluidics, electrochemical sensors / biosensors, and wireless electronics to make portable (sometimes wearable) monitoring devices for use as point of care devices that typically giving continuous real -time displays. He then uses these in a program of clinical science research focusing on the acute traumatic brain injury including that caused by cardiac arrest, neonatal continuous monitoring and kidney transplantation monitoring. He runs the EPSRC funded Bio-nanofabrication suite designed to make microfluidic and biosensor biosensors using scalable methods to allow use in proof-of-concept clinical trials.
Martyn is past president of the International Society for Monitoring Molecules in Neuroscience, and a founder of the COSBID organization for studying acute human brain injury. He published > 190 papers, chapters and patents. He obtained a BSc and PhD in Chemistry from Imperial College and worked as an EP Abraham Research Fellow in the University of Oxford.
Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame

Paul Bohn Biographical Sketch
Paul W. Bohn received the B.S. from the University of Notre Dame in 1977 and the Ph.D. from the University of Wisconsin-Madison in 1981, both in Chemistry. After two years at Bell Laboratories, he joined the faculty at the University of Illinois at Urbana-Champaign (UIUC). In 2006, he moved to the University of Notre Dame where he is currently the Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering, Professor of Chemistry and Biochemistry, and Director of the Institute for Precision Health. He served as Editor for the Americas for the RSC journal Analyst 2007-09 and as Chair of the Editorial Board 2010-14. Prof. Bohn is currently co-editor of Annual Review of Analytical Chemistry. His research interests include: (a) integrated nanofluidic and microfluidic chemical measurement strategies for personal monitoring, (b) chemical and biochemical sensing in mass-limited samples, (c) biochemical imaging, and (d) molecular approaches to nanotechnology, areas in which he has over 290 publications and 10 patents.
Rebecca Whelan, Associate Professor of Chemistry, University of Kansas

Rebecca Whelan Biographical Sketch
Prof. Whelan is Associate Professor of Chemistry at the University of Kansas. She is also affiliated with the Adams Institute for Bioanalytical Chemistry and the KU Cancer Center. She earned her Ph.D. at Stanford University and did postdoctoral research at the University of Michigan. Research during her independent career has focused on applications of separations, affinity agent development, and proteomics to ovarian cancer biomarker characterization and detection.
Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-scale System for Precision Medicine, The University of Kansas

Steve Soper Biographical Sketch
Prof. Soper (since 2016) is a Foundation Distinguished Professor in Chemistry and Mechanical Engineering at the University of Kansas. At KUMC, Prof. Soper holds an adjunct appointment in the Cancer Biology Department and is a member of the KU Cancer Center. He also holds an appointment at Ulsan National Institute of Science and Technology in Ulsan, South Korea, where he is a World Class University Professor.
As a result of his efforts, Prof. Soper has secured extramural funding totaling >$125M, has published over 245 peer-reviewed manuscripts (h index = 70; >17,000 citations); 31 book chapters and 71 peer-reviewed conference proceeding papers, and is the author of 12 patents. He is also the founder of a startup company, BioFluidica, which is marketing devices for the isolation and enumeration of liquid biopsy markers. Soper recently founded a second company, Sunflower Genomics, which is seeking to market a new DNA/RNA single-molecule sequencing platform. His list of awards includes Ralph Adams Award in Bioanalytical Chemistry, Chemical Instrumentation by the American Chemical Society, the Benedetti-Pichler Award for Microchemistry, Fellow of the AAAS, Fellow of Applied Spectroscopy, Fellow of the Royal Society of Chemistry, R&D 100 Award, Distinguished Masters Award at LSU and Outstanding Scientist/Engineer in the state of Louisiana in 2001. Finally, Prof. Soper has granted 50 PhDs and 7 MS degrees to students under his mentorship. He currently heads a group of 15 researchers.
His major discoveries include: (1) Technology for the detection of liquid biopsy markers that can manage a variety of diseases using a simple blood test (test has been demonstrated in multiple myeloma, pediatric acute lymphoblastic leukemia, acute myeloid leukemia, pancreatic, breast, colorectal, prostate, and ovarian cancers); (2) new hardware and assay for the point-of-care diagnosis of acute ischemic stroke; (3) single-molecule DNA and RNA sequencing nanotechnology; and (4) currently working on a home-test for COVID-19 infections (handheld instrument and the associated assay.
Tony Hu, Professor and Weatherhead Presidential Chair, Tulane University School of Medicine

Tony Hu Biographical Sketch
Dr. Tony Hu is a Professor in Biochemistry and Molecular Biology, Biomedical Engineering, and Microbiology at Tulane University. He is also the Weatherhead Presidential Chair in Biotechnology Innovation, founding Director of the Center for Intelligent Molecular Diagnostics at Tulane School of Medicine, and the fellows of National Academy of Inventors (NAI) and American Institute of Medical and Biological Engineering (AIMBE). Dr. Hu’s research focuses on engineered multi-omics, nanomedicine, mechanism-driven biomarker discovery and assay development. His research differs from conventional biomarker discovery and detection research for clinical microbiology in that it employs the special properties of nanomaterials to improve assay performance and reproducibility. His inventions are intended to serve as a model for the analysis of similar characteristics of infectious and malignant diseases to facilitate the development of a full spectrum of diagnostic, prognostic and treatment evaluation assays, and re-define the diagnostic criteria to differentiate disease stages using molecular tests as a long-term goal. His work has resulted in publications of over 150 high-impact papers, and 25 pat¬ent applications involving nanomedicine. Fourteen of those patents have been licensed by US-based or international companies. Dr. Hu’s lab has been consistently support¬ed by the DOD, NIH, Gates Foundation, WHO and others. Dr. Hu is also the co-founders of two biotech startup companies, Intelligenome Inc. in Houston, TX and NanoPin Technologies in New Orleans, LA.
Yoon-Kyoung Cho, Professor, Biomedical Engineering, Ulsan National Institute of Science & Technology; Group leader, IBS; FRSC, Fellow of Royal Society of Chemistry

Yoon-Kyoung Cho Biographical Sketch
Yoon-Kyoung Cho is a full professor of Biomedical Engineering at UNIST and a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS), Republic of Korea. She is a member of the National Academy of Engineering of Korea (NAEK) and a Fellow of Royal Society of Chemistry (FRSC). She serves as a director at the Chemical and Biological Microsystems Society (CBMS) and an associate editor for Lab on a chip. She received her Ph.D. in Materials Science and Engineering from the University of Illinois at Urbana-Champaign (UIUC) in 1999, having obtained her M.S. and B.S. in Chemical Engineering from POSTECH in 1994 and 1992, respectively. She worked as a senior researcher (1999–2008) at Samsung Advanced Institute of Technology (SAIT), where she helped create biomedical in vitro diagnostic instruments. Her research spans a broad spectrum from fundamental scientific exploration to translational efforts, focusing primarily on microfluidics and nanomedicine. Her current research topics include a lab-on-a-disc for the detection of rare cells and biomarkers, quantitative analysis of single cells, and system analysis of cellular communication. She published over 135 journal papers and over 205 issued patents, many of which helped Samsung Electronics and two start-ups (Clinomics and LabSpinner) build commercial products. Discover more at http://fruits.unist.ac.kr.
08:00
18 March 2024
Conference Entrance
Conference Registration, Materials Pick-Up and Networking
08:50
18 March 2024
Rotterdam Room
Session Title: Conference Opening Session - Dx Paradigms 2024
09:00
18 March 2024
Rotterdam Room
Conference Chair

Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-Scale System for Precision Medicine, The University of Kansas, United States of America
Screening Technologies for the Early Detection of Cancer: Current Challenges and Opportunities
Regardless of the significant improvement in treatment, cancer remains the leading cause of death worldwide accounting for nearly 10 million deaths in 2020. Other than the effects on patients and families, cancer has a tremendous impact on the economy of a country as well. Both mortality and healthcare costs for cancer care could be greatly reduced by early detection of large populations as once cancer has metastasized treatments become difficult and costly and survival rates drop precipitously. Although there is a one-in-three chance of being diagnosed with cancer in one’s lifetime, the screening of cancer in the general population is limited. Screening tests if designed properly can help find the disease early, which here is defined as a pre-metastatic state, when the disease outcome for a patient is more optimistic. Currently, only a few cancers including breast, cervical, colon, lung, and prostate cancers are screened among the general population. But, the current screening tests are not without challenges including modest clinical figures-of-merit, poor compliance, and high complexity in terms of assay format and the need for specialized operators. Thus, improvements in screening strategies will enable more of the general population to be tested resulting in reduced mortality rates. Current screening tests are limited by several factors such as lack of easily accessible markers, suboptimal compliance, low sensitivity for early-stage disease, high false positive rates, varied cost-effectiveness, and the need for complex clinical workflows. For instance, to date there is no screening test for the early detection of ovarian cancer. Although CA-125 blood tests are the most widely used test for ovarian cancer screening, it is not without significant challenges as CA-125 is also often elevated in the blood of people with other conditions such as endometriosis, fibroids, and liver cirrhosis. Thus, the CA-125 test is FDA approved only for assessing treatment efficiency after ovarian cancer diagnosis, as well as for monitoring recurrence. Hence, there is a large societal need to develop new screening technologies to address these drawbacks. We discuss the challenges in currently available screening technologies for cancer and the prospects for developing new screening tests including accessible biomarkers (i.e., liquid biopsy markers) and the associated hardware that would be of keen interest to the bioanalytical community.
10:00
18 March 2024
Exhibit Hall
Mid-Morning Coffee Break and Networking in the Exhibit Hall
11:00
18 March 2024
Rotterdam Room

Adam Hall, Associate Professor of Biomedical Engineering, Wake Forest School of Medicine, United States of America
Translational Detection of Diverse Biomarkers Using Solid-State Nanopore Detectors
Nanopore technology is uniquely capable to probing large populations of molecules electrically and on an individual basis. While biological (i.e. protein-based) nanopores have found utility in commercial analytical technologies like DNA and RNA sequencing devices (e.g. Oxford Nanopore), their artificial counterparts have so far been less successful in finding a translational foothold. This is at least partially because few straightforward measurements have been demonstrated for the platform to analyze translationally or clinically important markers that cannot easily be probed with existing technologies. In this presentation, I will discuss our progress in developing solid-state nanopore assays capable of assessing several molecular targets that are difficult to probe by other means. These will include DNA epigenetic modification/lesions, microRNAs, and the glycan hyaluronan.
11:30
18 March 2024
Rotterdam Room

Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame, United States of America
Hierarchically Organized Block Copolymer-Nanopore Electrode Arrays for Electrochemical Biosensing of Disease Biomarkers
Hydrophobic gating in biological transport proteins is regulated by stimulus-specific switching between filled and empty nanocavities, endowing them with selective mass transport capabilities. Inspired by these, solid-state nanochannels have been integrated into functional materials to realize electrochemical biosensors with integral mass transport control. Hierarchically organized structures are composed of polystyrene-b-poly(4-vinyl)pyridine (PS-b-P4VP) block copolymer on two-electrode nanopore electrode arrays (BCP@NEAs) housing target-specific enzymes. The BCP enables potential-responsive gating, making it possible to capture and confine analyte species in the attoliter-level NEA volume, enabling redox cycling and current amplification factors >100X. The enzyme-coupled sensing capabilities have been demonstrated with a variety of substrates, including cytokines (IL-6, TNF-alpha), metabolites from lipid nanoparticle degradation, and environmentally-relevant markers. Limits-of-detection <70 fM are obtained in favorable cases. The mass transport-controlled sensing platform described is relevant to next-generation point-of-care devices.
12:00
18 March 2024
Exhibit Hall
Networking Buffet Lunch in the Exhibit Hall -- Networking with Colleagues, Engage with Exhibitors and View Posters
13:25
18 March 2024
Rotterdam Room
Session Title: Circulating Biomarkers as Starting Materials for Dx Development
13:30
18 March 2024
Rotterdam Room

Brian Cunningham, Professor and Intel Alumni Endowed Chair, University of Illinois at Urbana-Champaign, United States of America
Ultra-sensitive Digital Molecular and Viral Assays for Point of Care Diagnosis Using Photonic Crystal Biosensor Microscopy
By combining biosensor microscopy that provides high contrast for detecting individual biomolecules and viruses with novel biochemistry methods that can effectively turn each target molecule into many digitally-counted sensing events, it is possible to achieve attomolar-scale limits of detection for cancer-specific nucleic acid target molecules (miRNA and ctDNA) while simultaneously obtaining thousands-to-one selectivity against single base variants. The presentation will describe the use of photonic metamaterials and associated detection instruments to amplify optical absorption and fluorescence emission. The biodetection technology platforms are used to perform assays using nucleic acid strand displacement reactions and CRISPR/Cas chemistry to sense target biomarkers from complex media. We also utilize DNA origami probes in the shape of hand-like “nano-grippers” that selectively recognize and bind with the outer surface proteins of viruses. The “amplify-then-digitize” approach represents a new and powerful paradigm for molecular and viral diagnostics, compared to the “digitize-then-amplify” approach utilized in methods such as droplet digital PCR (ddPCR). Overall, we seek simple, rapid, room temperature, single-step assay methods that can be operate with small, inexpensive, and robust detection systems for applications in point of care diagnostics, laboratory-based diagnostics, and life science research applications.
14:00
18 March 2024
Rotterdam Room

Daniel Chiu, A. Bruce Montgomery Professor of Chemistry, University of Washington, United States of America
Digital Flow Cytometry for the Analysis of Single Extracellular Vesicles and Particles
We have developed a multi-parametric high-throughput flow-based method for the analysis of individual extracellular vesicles and particles (EVPs), which are highly heterogeneous and comprise a diverse set of surface protein markers as well as intra-vesicular cargoes. Yet, current approaches to the study of EVPs lack the necessary sensitivity and precision to fully characterize and understand the make-up and the distribution of various EV subpopulations that may be present. Digital flow cytometry (dFC) provides single-fluorophore sensitivity and enables multi-parameter characterization of EVPs, including single-EVP phenotyping, sizing, and the absolute quantitation of EVP concentrations and biomarker copy numbers. dFC has a broad range of applications, from analysis of single EVPs such as exosomes or RNA-binding proteins to characterization of therapeutic lipid nanoparticles, viruses, and proteins. dFC also provides absolute quantitation of non-EVP samples such as dyes, beads, and Ab-dye conjugates.
14:30
18 March 2024
Rotterdam Room

Hyungsoon Im, Associate Professor, Center for Systems Biology, Mass General Hospital (MGH)/Harvard Medical School, United States of America
Molecular Analysis of Extracellular Vesicles for Cancer Diagnosis and Treatment Monitoring
In this presentation, I will discuss our recent developments of plasmon-enhanced single extracellular vesicles analysis for cancer diagnosis and drug resistant detection during cancer therapy.
15:00
18 March 2024
Rotterdam Room

Tony Hu, Professor and Weatherhead Presidential Chair, Tulane University School of Medicine, United States of America
EV-based Omics Analysis Enabling Personalized Diagnosis
Diagnostics for infectious and malignant diseases often exhibit poor specificity/sensitivity, hindering early detection and treatment evaluation, but development of improved assays is limited by several challenges, including absence of disease-specific factors, low biomarker concentrations, and interfering factors. We have employed an array of sensitive analytic technology platforms to identify key host-pathogen interactions that influence pathogenesis and applies this information to identify diagnostic and predictive biomarkers that can be applied for personalized medicine to improve patient outcomes. We reported the development and validation of several nanotechnoloy-based assays platforms that can be used to quantify protein and nucleic acid changes in EV-associated protein biomarkers, and which have the capacity to target EVs derived from specific cell populations, including EVs derived from Mtb-infected phagocytes and other cell populations involved in granuloma formation. Candidate biomarkers identified will be analyzed using these platforms and correlated with changes in specific granuloma and systemic cell populations.
15:30
18 March 2024
Exhibit Hall
Mid-Afternoon Coffee Break and Networking in the Exhibit Hall
16:00
18 March 2024
Rotterdam Room

David Wong, Felix and Mildred Yip Endowed Chair in Dentistry; Director for UCLA Center for Oral/Head & Neck Oncology Research, University of California-Los Angeles, United States of America
Saliva EFIRM Liquid Biopsy
Circulating free DNA (ctDNA) liquid biopsy is rapidly emerging to address the unmet clinical need to detect signature mutations in human cancer based on cell-free circulating tumor DNA (ctDNA) as a surrogate for the tumor genome. The detection of ctDNA via liquid biopsy will facilitate analysis of tumor genomics needed for early detection, molecular targeted therapy, treatment monitoring, onset of acquired resistance mutations, recurrence and minimal residual diseases. Currently, most liquid biopsy approaches are plasma-based using PCR and/or next generation sequencing (NGS) with performance concordance in the 60-70% range compared with biopsy-based genotyping. The exciting horizon ctDNA liquid biopsy is hampered by low copy number of ctDNA, volume requirement for assays and sensitivity of detection platform. Saliva is a bodily fluid that we produce ~600ml per day and harbors multiple omics constituents, including ctDNA that can be harnessed non-invasive for personalized and precision medicine applications, is ideal for ctDNA liquid biopsy. Yet conventional PCR-based technologies cannot detect ctDNA in saliva samples whereas an emerging liquid biopsy platform “Electric Field Induced Release and Measurement (EFIRM)” consistently detect ctDNA from NSCLC patients with actionable mutations in plasma and saliva with concordance of 95%+ with tissue/biopsy-based genotyping including early-stage lesions. EFIRM provides the most accurate targeted detection that can assist clinical treatment decisions for non-small cell lung cancer (NSCLC), with tyrosine kinase inhibitors (TKI) that can extend the disease progress free survival period of these patients. The mechanism of EFIRM for ctDNA detection was recently revealed to detect ctDNA that are ~45 bp single-stranded ctDNA we termed ultra-short ctDNA (usctDNA), whereas the conventional ctDNA are mononucleosomal that are ~160 bp and double-stranded. Conventional ddPCR or NGS cannot detect usctDNAs, where a minimum of 78-bp is needed for amplification. Custom design of ddPCR assay to quantify the EGFR L858R usctDNA in saliva of NSCLC patients revealed that the usctDNA is present at high abundance, mean= 62,636; SD ± 63,334, range: 16,500 to 56,375 copies per mL of saliva, permitting its detection in small saliva volume of 50uL or less, directly without sample processing. These results led to the conclusion that there is an emerging landscape of usctDNA that is present at much higher stoichiometry than mononucleosomal ctDNA permitting detection by the EFIRM technology in micro-litter volume of saliva samples, directly without processing, presenting a new frontier for ctDNA liquid biopsy, addressing the low copy number and limit of detection bottleneck of mnctDNA liquid biopsy.
16:30
18 March 2024
Rotterdam Room

Rebecca Whelan, Associate Professor of Chemistry, University of Kansas, United States of America
New Insights on Ovarian Cancer Biomarker CA125
Through a combination of long-read sequencing, proteomics, and mutation analysis, the Whelan lab has recently developed a new model for the ovarian cancer biomarker CA125. These results and remaining questions will be presented.
17:00
18 March 2024
Rotterdam Room

Yoon-Kyoung Cho, Professor, Biomedical Engineering, Ulsan National Institute of Science & Technology; Group leader, IBS; FRSC, Fellow of Royal Society of Chemistry, Republic of Korea
Lab-on-a-Disc For Precision Medicine
Liquid biopsy is a promising alternative to tissue biopsy for cancer clinics, as it can provide valuable information on circulating biomarkers and aid in treatment planning for individual patients. However, the process can be expensive, complex, and requires large sample volumes, with low sensitivity being a significant limitation. To address these challenges, we have developed "lab-on-a-disc" systems that utilize centrifugal force to analyze cancer-related biomarkers in biological fluids such as blood or urine. Our system can isolate and detect liquid biopsy markers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vesicles (EVs). We have tested our system using clinical samples from cancer patients and are excited to introduce our fluid-assisted separation technology, which allows for fast, uniform, clog-free, and efficient filtration. Additionally, we will discuss our recent studies on the potential of extracellular vesicles (EVs) as cancer biomarkers, which could have significant implications for cancer diagnostics. In addition, we will introduce a hand-powered centrifugal bacterial isolation device to determine the bacterial load and to test antibiotics susceptibility which is designed for the usage in resource-limited settings. We believe that our innovative microfluidic tools can accelerate the translation of liquid biopsy technology into real clinical settings, directly impacting patient care.
17:30
18 March 2024
Pillars Bar
Networking Beer and Wine Reception - Network and Engage with Colleagues in the Pillars Bar
18:30
18 March 2024
Close of Day 1 Conference Programming
08:00
19 March 2024
Exhibit Hall
Morning Coffee, Pastries and Networking in the Exhibit Hall
09:00
19 March 2024
Rotterdam Room

Andrew Godwin, Professor and Division Director, Genomic Diagnostics, Founding Director, Kansas Institute for Precision Medicine, Deputy Director, KU Cancer Center, University of Kansas Medical Center, United States of America
Liquid Gold in Precision Medicine: Exploiting Extracellular Vesicles as Biomarkers to Diagnose and Monitor Cancer
Pathologic analysis of tumor tissue biopsies is the gold standard for the initial diagnosis of cancer. However, recently liquid biopsies, which analyze tumor-derived material circulating in the bloodstream and other bodily fluids, are rapidly gaining traction in the clinic. These tests offer considerable potential in oncology, which include early detection, monitoring treatment response and disease recurrence. Liquid biopsy biomarkers include circulating tumor cells, cell-free DNA, nanoparticles, and extracellular vesicles (EVs). Regarding the latter, EVs are showing great promise as circulating biomarkers. The International Society for Extracellular Vesicles define EVs as particles naturally released from the cell that are delimited by “a lipid bilayer and cannot replicate”. Central among EVs are nano-sized vesicles (ranging from 40 to 150 nm in diameter) of endocytic origin also known as small EVs/exosomes, which are produced and released by most cell types under normal physiologic and in diseased states. sEVs carry cargo representative of their originating cell including nucleic acids, cytokines, membrane-bound receptors, and a wide assortment of other, biologically active lipids and proteins. Since sEVs travel systemically throughout the body, efforts are underway to exploit them as potential biomarkers to detect and monitor disease states. Ways to exploit sEVs for cancer diagnostics and monitoring response to therapy will be discussed.
09:30
19 March 2024
Rotterdam Room

Martyn Boutelle, Professor of Biomedical Sensors Engineering, Imperial College London, United Kingdom
Real-Time Point-of-Care Diagnostics Using Microfluidic Sensors and Biosensors
We are investigating technologies that take POC measurements from a moment in time that assists diagnosis to a continuous information stream that guides treatment dynamically. Biomarker molecule concentrations can give important information about the health of a person as they are dynamically challenged by acute illness or for example during clinical treatment. Such an approach would allow individualized treatments to be chosen and optimized. We have been developing a range of sensing and biosensing solutions for the invasive, minimally invasive, and non-invasive monitoring of people in healthcare situations. Microfluidics provide a valuable means of clinical sampling and robust quantification of measured signals.
I will describe the key challenges in the development of such integrated sensing devices and present our recent data obtained during models of cardiac arrest and from the neonatal intensive care unit.
10:00
19 March 2024
Rotterdam Room

Erik Vollebregt, Partner, Axon Lawyers, The Netherlands
Recent Developments in IVDR, Including Another Proposal to Change the Transitional Regime
When it comes to the IVDR the constant is change. While companies in the IVDR sector are navigating this new regulatory system for IVDs for Europe the transitional regime keeps changing, with a new amendment proposed for the transitional regime last January. The presentation will address all recent regulatory developments relevant to IVD companies doing business in Europe.
10:30
19 March 2024
Exhibit Hall
Mid-Morning Coffee Break and Networking in the Exhibit Hall
11:00
19 March 2024
Rotterdam Room

Jaebum Choo, Professor, Chung-Ang University, Republic of Korea
Toward Rapid and Sensitive Point-of-Care Diagnosis of COVID-19 with Nanoplasmonic Sensing Platforms
The SARS-CoV-2 pandemic is causing severe social and economic problems worldwide. RT-PCR has been considered the gold standard for detecting SARS-CoV-2 target genes. However, in RT-PCR, the total diagnostic time, including sample preparation, gene amplification, and detection, takes approximately 3-4 hours. Thus, it is critical to shorten the diagnostic time for rapid on-site diagnosis. Various rapid kits for immune diagnosis, using antigen-antibody reactions, have also been developed to shorten the diagnosis time. However, they have not been adopted as the standard diagnostic method due to their poor sensitivity and accuracy. In particular, the "false-negative" problem of commercialized immunodiagnostic kits is recognized as a severe issue that can exacerbate the spread of SARS-CoV-2. To address these issues, we have developed innovative nanoplasmonic assay platforms with a portable Raman reader for rapid and sensitive diagnostics of SARS-CoV-2 in the field. This technique enables the detection of SARS-CoV-2 with a limit of detection (LoD) of less than 5.0 PFU/mL within 15 minutes. The results of this study demonstrate the possibility of clinical application that can significantly improve the detection limit and accuracy of currently commercialized SARS-CoV-2 immunodiagnostic kits.
11:30
19 March 2024
Rotterdam Room
Closing Comments, Ideas, Feedback from the Summit Chairperson -- Professor Dr. Steve Soper
12:00
19 March 2024
Exhibit Hall
Networking Buffet Lunch in the Exhibit Hall -- Networking with Colleagues, Engage with Exhibitors and View Posters
13:30
19 March 2024
Close of Summit