
Advances in Extracellular Vesicle & Biomimetic Science 2025
Date: Monday, December 1, 2025 - Tuesday, December 2, 2025
Location: Baylor College of Medicine -- Houston, Texas
Confirmed Speakers

Biana Godin, Associate Professor, Department of Nanomedicine, Houston Methodist Research Institute

Fernanda Kugeratski, Instructor, The University of Texas MD Anderson Cancer Center

Jacqueline Parchem, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, UTHealth Houston

Laura Goetzl, Professor and Vice Chair for Translational Research, The University of Texas, MD Anderson Caner Center

Swathi Balaji, Associate Professor, Baylor College of Medicine and Texas Children’s Hospital

Wei-Chuan Shih, Cullen Engineering Endowed Professor, University of Houston; Founder-CEO, Seek Diagnostics

Ziwen Wang, Field Application Scientist, EXODUS BIO

Bruna Corradetti, Assistant Professor, Center for Precision Environmental Health, Department of Medicine, Baylor College of Medicine -- Conference Chairperson

Francesca Taraballi, Associate Professor of Orthopedic Surgery, Houston Methodist Research Institute

Kate McAndrews, Assistant Professor, Department of Cancer Biology, MD Anderson Cancer Center

Sara Corvigno, Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson

Theocharis Panaretakis, Associate Professor, GU Medical Oncology, MD Anderson Cancer Center

William K. Decker, Professor, Baylor College of Medicine

Carly Filgueira, Assistant Professor of Nanomedicine & Cardiovascular Surgery, Houston Methodist Research Institute

George A. Calin, Chair, Department of Cancer Biology Department, Division of Discovery Science, The University of Texas MD Anderson Cancer Center

Kelsey Swingle, Assistant Professor, Department of Bioengineering, Rice University

Surjya Dash, Senior Scientist, Department of Nephrology, School of Medicine, University of Virginia

Tiziana Corsello, Assistant Professor, Department of Pediatrics, CEIID Research, University of Texas Medical Branch

Yi-Ping Li, Professor, Department of Integrative Biology and Pharmacology, UTHealth Houston
Overview of the Conference
SelectBIO Advances in Extracellular Vesicle & Biomimetic Science will be held December 1-2, 2025 at the Baylor College of Medicine in Houston, Texas.
SelectBIO is honored to welcome Professor Bruna Corradetti, Center for Precision Environmental Health, Department of Medicine -- Section of Hematology/Oncology at the Baylor College of Medicine as the Chairperson of the Conference.
This conference brings together academic researchers from across Texas Medical Center in Houston, researchers from across Texas and the US in a focused 2-day event featuring academic presentations on cutting-edge science, company presentations, technology/tools vendor presentations and instrumentation demos plus exhibitors and networking opportunities.
The conference welcomes doctoral students, post-doctoral and research fellows to submit abstracts for oral presentations on their research as it relates to the goals of this conference -- featuring the latest research, engaging researchers and companies, and extensive networking and collaboration opportunities.
Call for Abstracts
Agenda Topics
You can also present your research in an oral presentation while attending the meeting. Submit an abstract for consideration under the Submissions tab of this conference website
Oral Presentation Abstract Submission Deadline: November 20, 2025
Emerging Areas in Exosomes/EV Research
Various Platforms for the Isolation of Exosomes/EVs
Characterization of Exosomes/EVs
Downstream Analysis of Exosomes/EV Cargo -- RNAs, Proteins and Lipids
Platforms for Single Exosome/EV Analysis -- Flow Cytometry
Advancements in Technologies and New Disruptive Technologies in EV Research
Lipid Nanoparticles (LNPs)
Sponsorship and Exhibition Opportunities
Delegate Registrations Online Processing
Any questions or assistance during registration, please call us at: +1 (510) 857-4865 or e-mail us at: Contact SelectBIO
Gold Sponsors
Exhibitors
Sponsorship and Exhibition Opportunities
If you require any information about exhibiting or sponsoring at one of our events please contact Jeff Fan using the information below:
Jeff Fan
Exhibition Manager - SelectBIO Conferences
Why Sponsor-Exhibit at a SelectBIO Conference?
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We don’t forget you after you sign on the bottom line either as our customer service dept. will alert you to all the things you need to think about up to and during the event itself.
Advances in Extracellular Vesicle & Biomimetic Science Conference Venue
SelectBIO is pleased to host this Advances in Extracellular Vesicle & Biomimetic Science Conference in Houston, Texas.
Baylor College of Medicine
One Baylor Plaza
Michael E. DeBakey Center, Kleberg Auditorium
1 Baylor Plaza
Houston, TX 77030
Houston is a world-class city with excellent hotels, excellent transportation infrastructure and airports enabling access from cities across the United States and Worldwide.
George Bush Intercontinental Airport (airport code: IAH) hosts major airlines and offers seamless connections worldwide.
Rideshare via Uber available from IAH airport to destinations across Houston for easy access.
**Shortly, SelectBIO will announce hotels where participants can stay close to the conference venue**




For any questions with the venue or logistics matters, please kindly contact SelectBIO Conferenes:
Jeff Fan
Events Manager, SelectBIO Conferences
E-mail: Jeff@selectbioconferences.com
SelectBIO has NOT authorized ANY third party company to assist in hotel bookings or any bookings or reservations for this conference. Please do NOT do business with any third party companies. If in doubt, please contact Jeff Fan immediately to clarify.
Register to this conference and also enjoy the following co-located events at no extra charge.
Training Courses
If you would like to submit a proposal for an oral or poster presentation at this meeting, please fill out the form below required for your submission.
Successful applicants will be provided with all necessary information.
Abstract Content:
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Written in English
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Written in the third person
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Include title, name(s) and affiliation(s) of the authors
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Between 100 - 200 words
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Suitable for direct publication in the proceedings pack and on the website
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Related to the subject of the conference
Agenda Topics
Emerging Areas in Exosomes/EV Research
Various Platforms for the Isolation of Exosomes/EVs
Characterization of Exosomes/EVs
Downstream Analysis of Exosomes/EV Cargo -- RNAs, Proteins and Lipids
Platforms for Single Exosome/EV Analysis -- Flow Cytometry
Advancements in Technologies and New Disruptive Technologies in EV Research
Lipid Nanoparticles (LNPs)
Copyrights
The presenting author/person who submitted the abstract assumes full responsibility of the content of the abstract and we assume that all co-authors are aware of this content. Please note that your biography, summary and abstract may be used on this website and conference materials.
Biana Godin, Associate Professor, Department of Nanomedicine, Houston Methodist Research Institute

Biana Godin Biographical Sketch
Dr. Biana Godin earned her Ph.D. in Pharmaceutical Sciences from the School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel. She is an Associate Professor at the Department of Nanomedicine in Houston Methodist Research Institute (HMRI), Weill Cornell Medical College (WCMC) Department of Obstetrics and Gynecology (Ob/Gyn) and Department of Ob/Gyn, Center for RNA therapeutics and Cancer Center at Houston Methodist Hospital (HMH) and have Adjunct Appointments at the Ob/Gyn Department of School of Medicine, UTHealth and Department of Biomedical Engineering, Texas A&M College Station. Research in Dr. Godin’s lab, funded by federal, state and foundation grants with >$7M in total funding over the years, focuses on developing physiologically relevant in vitro/in vivo disease models and exploiting physical and biological mechanisms to improve currently available therapeutic options in oncology, obstetrics, wounds healing and infectious diseases. Dr. Godin’s track record has >250 research publications including high-profile original papers, reviews and invited/keynote presentations at national and international meetings with >50K reads (ResearchGate) and >15K citations (i10 index 86 Google Scholar).
Bruna Corradetti, Assistant Professor, Center for Precision Environmental Health, Department of Medicine, Baylor College of Medicine -- Conference Chairperson

Bruna Corradetti Biographical Sketch
Dr. Bruna Corradetti is a translational scientist and professor whose research lies at the intersection of regenerative medicine, biomaterials, and stem cell biology. With a strong foundation in stem cell-based therapies and immunomodulatory biomaterials, her work focuses on developing innovative, cell-free therapeutic strategies, ranging from extracellular vesicles to RNA-enhanced biomimetic patches, that harness the body’s natural healing processes. These minimally invasive approaches are designed to improve chronic wound healing and address congenital malformations.
Dr. Corradetti holds a faculty position at Baylor College of Medicine (USA) and is an affiliated investigator at both the Houston Methodist Research Institute (USA) and Swansea University Medical School (UK). Her research is supported by federal agencies and philanthropic foundations and reflects a deeply translational approach, informed by training and appointments across premier institutions in Europe and the United States.
In 2022, she was named one of 20 Innovative Investigators in Texas by the TMC Innovation Advanced Cancer Therapeutics (ACT) program, in recognition of her pioneering work on exosome-based vaccines aimed at preventing ovarian cancer recurrence. Internationally recognized for her scientific leadership, Dr. Corradetti was included among the 100 Italian Excellences in 2017. She was the first woman appointed to the Scientific Board of the European Society for Translational Medicine and received the Business and Professional Women-CUP Leadership Award in 2019 for her efforts in advancing gender equity in STEM.
Her TEDx talk, “The Power of Resilience in Science,” and her feature in Fortune Italia underscore her commitment to mentoring early-career scientists and building inclusive, supportive research environments.
Carly Filgueira, Assistant Professor of Nanomedicine & Cardiovascular Surgery, Houston Methodist Research Institute

Carly Filgueira Biographical Sketch
Dr. Carly S. Filgueira is an Assistant Professor in the Departments of Nanomedicine and Cardiovascular Surgery at Houston Methodist Research Institute, where she leads research at the intersection of nanotechnology and cardiovascular science. Dr. Filgueira earned her Bachelor of Science in Chemistry, magna cum laude, from The George Washington University, where she began her scientific career exploring nanoparticle-biopolymer chemistry with spectroscopy. She then completed her MS and PhD in Chemistry at Rice University under the mentorship of Dr. Naomi Halas, fabricating and characterizing optically responsive nanostructures and studying their plasmonic properties. Throughout her academic training, Dr. Filgueira received numerous honors, including the NIH Keck Nanobiology Fellowship, an NSF award to attend the Lindau Nobel Laureate Meeting in Germany, and multiple research and service awards from Rice University. In 2011, she joined Houston Methodist as a postdoctoral fellow, focusing on nuclear hormone receptors and small molecule screening. She later rose to the rank of Assistant Professor, where her independent research centers on developing sustained release nanotechnological therapies for physiological disorders, with particular interest in metabolic syndrome, cardiovascular disease, and hormone replacement therapy. Her laboratory is recognized for its multidisciplinary approach, leveraging nanomedicine to devise alternative treatment strategies ranging from bone growth to heart repair. She has over 50 publications in various high impact journals and has experience in managing and leading projects funded by the Golfers Against Cancer, Kostas Cardiovascular Nanomedicine Grant, Simmons Mini Collaborative Fund, and U.S. Department of Defense (five different funded awards). With the support of the John S. Dunn Foundation Collaborative Research Award Program, the team has been able demonstrate photoacoustic imaging (PAI) using gold nanorods as a contrast agent for real-time, high-resolution, low-noise cardiac tissue visualization. She balances her research leadership with mentorship of diverse trainees, and her work is distinguished by its translational potential and commitment to advancing both fundamental and clinical science in cardiovascular health.
Fernanda G. Kugeratski, Instructor, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center

Fernanda Kugeratski Biographical Sketch
Dr. Fernanda G. Kugeratski is a cancer biologist focused on unraveling new mechanisms of intercellular communication within the tumor microenvironment. She holds a faculty position in the Department of Experimental Therapeutics at The University of Texas MD Anderson Cancer Center, and her research program focuses on defining how secreted entities from cancer-associated fibroblasts modulate the immune system in cancer.
Francesca Taraballi, Associate Professor of Orthopedic Surgery, Houston Methodist Research Institute

Francesca Taraballi Biographical Sketch
Francesca Taraballi, Ph.D. is an Associate Professor of Orthopedic Surgery at the Houston Methodist Research Institute, where she directs the Center for Musculoskeletal Regeneration. Trained in biochemistry, structural biochemistry, and nanotechnology, Dr. Taraballi’s research focuses on immunoengineering and biomimetic materials for tissue regeneration, cancer therapy, and RNA-based therapeutics. Her lab develops nature-inspired nanomedicines—such as lipid nanoparticles and extracellular vesicle mimetics—to modulate the immune system for improved healing and targeted drug delivery.
George A. Calin, Chair, Department of Cancer Biology Department, Division of Discovery Science, The University of Texas MD Anderson Cancer Center

George A. Calin Biographical Sketch
Chair, Department of Cancer Biology Department, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, Texas
Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
2000 Carol Davila University of Medicine and Pharmacy, Bucharest, RO, Faculty of Medicine, Ph.D
1992 Carol Davila University of Medicine and Pharmacy, Bucharest, RO, MD
2000-2004 Specialist, Gastroenterology, Fundeni University Hospital, Bucharest
2000-2000 Chief, HLA genotyping laboratory, Fundeni University Hospital, Bucharest
2000-2004 Post-Doctoral Fellow, Kimmel Cancer Institute-Thomas Jefferson University, Philadelphia, Pennsylvania
1999-2000 Staff Member, Molecular Genetics Laboratory, National Institute of Legal Medicine, Bucharest
1997-1999 Postdoctoral Fellow, Molecular Genetics, University of Ferrara, Ferrara
1994-2000 Resident, Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest
1992-1994 Intern, Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest
Jacqueline Parchem, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, UTHealth Houston

Jacqueline Parchem Biographical Sketch
Jacqueline Parchem, MD, is a maternal-fetal medicine physician-scientist at The University of Texas Health Science Center at Houston (UTHealth Houston). Her research focuses on advancing the understanding of pregnancy disorders to improve maternal and child health.
Kate McAndrews, Assistant Professor, Department of Cancer Biology, MD Anderson Cancer Center

Kate McAndrews Biographical Sketch
Dr. Kate McAndrews, Ph.D. completed her B.S. in Chemical Engineering from the University of Nevada Reno in 2010. She completed her Ph.D. in Chemical and Biomolecular Engineering at the Georgia Institute of Technology in the laboratory of Dr. Michelle Dawson in 2015, where she trained as a matrix bioengineer with a specific focus on understanding the influence of molecular and mechanical cues provided by the microenvironment on mesenchymal stem cell (MSC) function in tissue regeneration and cancer progression. Dr. McAndrews joined the laboratory of Dr. Raghu Kalluri at the University of Texas MD Anderson Cancer Center for her postdoctoral training in 2015. Her work has focused on novel biology of extracellular vesicles (EVs)/exosomes, their role in cancer, and their utility as therapeutic vehicles as well as the functional role of fibroblasts in tissue repair and cancer. Dr. McAndrews’s postdoctoral work was supported by an Ergon Foundation Postdoctoral Fellowship and received an NIH K22 award to start her independent lab in 2024. She was also selected as the Dilip Mullick Early Career Scholar in Basic Pancreatic Cancer Research and a Shelby-Lavine Pancreatic Scholar in 2025. Her research group focuses on how the stresses induced by tissue damage remodel the microenvironment to facilitate disease progression and response to therapy. Her group is specifically interested in intracellular communication within the microenvironment mediated by extracellular vesicles (EVs) as well as ECM interactions and remodeling. Recently, she has developed an EV-based vaccine platform for infectious disease and cancer (Luo, McAndrews, et al. Journal of Controlled Release 2024) and identified a role for T cell-mediated clearance of cancer cells in the efficacy of KRAS inhibition (Mahadevan, McAndrews, et al. Cancer Cell 2023, McAndrews et al. Science Translational Medicine 2025, McAndrews et al. Under revision). Currently, her total citations are 6168 and her h-index is 29.
Kelsey Swingle, Assistant Professor, Department of Bioengineering, Rice University

Kelsey Swingle Biographical Sketch
I am an Assistant Professor at Rice University in the Department of Bioengineering. I completed my Bachelor's degree in Biomedical Engineering from Case Western Reserve University in 2020 and my Ph.D. in Bioengineering from the University of Pennsylvania in 2025. At Rice University, I am also a member of the Leadership Counsel for Rice Biotechnology Launch Pad which aims to accelerate the translation of biotechnology therapeutics from bench to bedside in less than five years. Through the Launch Pad, I have built a network of industry leaders, venture capital investors, regulatory advisors, and entrepreneurs who have experience translating therapeutics from academia to funded clinical trials. I have established collaborative relationships with clinical partners and physician-scientists in the Texas Medical Center—the largest medical center in the world that lies across the street from Rice University. My research has resulted in >30 publications at the interface of bioengineering, drug delivery, women's health, bioinformatics, and immune engineering. For this research, I was awarded three years of funding ($5.03M) from Wellcome Leap's program titled "The Missed Vital Sign" towards designing an RNA therapeutic for the treatment of heavy menstrual bleeding.
My lab's research at Rice University lies at the interface of biomaterials and drug delivery, immunology, and reproductive medicine with a specific focus on engineering therapeutic and vaccine technologies to both fundamentally understand and target important biological barriers that exist in tissues such as the placenta, vagina, uterus, and ovaries. My research combines the multi-scale formulation of biomaterials, molecule barcoding high-throughput screening approaches, microfluidic device fabrication, synthetic chemistry, and in vivo biomedical imaging to innovate novel delivery platforms and cells for applications in (i) reproductive disorders, (ii) cancer immunotherapy, (iii) gene editing and gene therapy, and (iv) infectious disease vaccines.
Laura Goetzl, Professor and Vice Chair for Translational Research, The University of Texas, MD Anderson Caner Center

Laura Goetzl Biographical Sketch
Dr. Goetzl is an NIH funded researcher and Maternal Fetal Medicine specialist. Her research focuses on extracellular based biomarkers of fetal brain injury secondary to exposure to drugs, infection and/or hypoxia. In addition, her work leverages EV biomarkers as measures of drug exposure at the target organ (brain) as an adjunct to pharmacologic studies.
Sara Corvigno, Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson

Sara Corvigno Biographical Sketch
I am a translational physician-scientist with deep expertise in the ovarian tumor micro-environment working particularly on tissue-based predictive biomarker and novel therapeutics research.
Surjya Dash, Senior Scientist, Department of Nephrology, School of Medicine, University of Virginia

Surjya Dash Biographical Sketch
Dr. Surjya Dash is a Senior Scientist in the Department of Nephrology, University of Virginia School of Medicine, where he works with Dr. Uta Erdbruegger to elucidate the mechanistic role of extracellular vesicles (EVs) as both biomarkers and mediators of cellular dysfunction in metabolic syndrome (MetS).
Trained in diabetes, nephrology, ciliopathies, and stem cell biology, his research integrates molecular and translational approaches to uncover pathways driving renal injury and systemic metabolic disturbances. His work specifically focuses on delineating mechanisms of kidney damage in diabetes, identifying early and predictive biomarkers of disease progression, and advancing EV-based diagnostic and therapeutic strategies. Dr. Dash earned his Ph.D. in stem cell biology from Utkal University, India, and has made significant contributions to embryonic stem cell line derivation, characterization and autologous stem cell therapy in both human and model systems. He has published extensively in peer-reviewed journals and maintains active collaborations with leading national and international research groups to accelerate discovery and therapeutic innovation in nephrology and metabolic disease.
Swathi Balaji, Associate Professor, Baylor College of Medicine and Texas Children’s Hospital

Swathi Balaji Biographical Sketch
Theocharis Panaretakis, Associate Professor, GU Medical Oncology, MD Anderson Cancer Center

Theocharis Panaretakis Biographical Sketch
Dr. Theocharis Panaretakis is an Associate Professor in the Department of Genitourinary Medical Oncology. He earned his PhD from Karolinska Institutet, where he specialized in cancer cell death modalities. During his postdoctoral training at Institut Gustave Roussy, he expanded his expertise in immunology, focusing on the immunogenicity of cell death as an anti-cancer strategy to stimulate immune responses. For the past decade, Dr. Panaretakis has investigated extracellular vesicles (EVs) as sources of predictive and prognostic biomarkers in circulation and as mediators of homotypic and heterotypic intercellular communication within the tumor microenvironment. His laboratory has developed molecular tools enabling longitudinal monitoring of prostate cancer progression and therapeutic response. Co-clinical studies from his group demonstrated the feasibility of tracking resistance to androgen receptor pathway inhibitors (ARPi) through specific EV markers in circulation, paving the way for EV-based approaches to monitor treatment response and uncover mechanisms of resistance. Dr. Panaretakis’ research has also shown that differential molecular profiles of EVs provide insights into the bone tumor microenvironment and its dynamic changes during treatment with agents such as Radium-223 and chemotherapy.
Tiziana Corsello, Assistant Professor, Department of Pediatrics, CEIID Research, University of Texas Medical Branch

Tiziana Corsello Biographical Sketch
Dr. Corsello, PharmD, PhD, is an Assistant Professor in the Department of Pediatrics, Division of Clinical and Experimental Immunology and Infectious Diseases, at the University of Texas Medical Branch (UTMB) in Galveston, and a member of the UTMB Sealy Center for Lung Disease Inflammation and Remodeling. She earned her PhD in Neuroscience from UTMB and completed postdoctoral training as a NIEHS T32 fellow in Environmental Toxicology and a Jeane B. Kempner Scholar. Her research investigates viral, environmental, and host factors driving respiratory viral infections in children, with a focus on biomarkers of smoke exposure and novel therapeutic antiviral strategies. She has received multiple prestigious awards, including the Rotary Foundation Global Scholar Award, Parker B. Francis Fellowship, American Lung Association Catalyst Award, and KL2 Provost Award.
Wei-Chuan Shih, Cullen Engineering Endowed Professor, University of Houston; Founder-CEO, Seek Diagnostics

Wei-Chuan Shih Biographical Sketch
Wei-Chuan Shih is Cullen College of Engineering Endowed rofessor of Electrical Engineering, Biomedical Engineering, Materials Science & Engineering, and Chemistry at the University of Houston (UH). He earned his Ph.D. from MIT Spectroscopy Lab and joined University of Houston after a stint as Schlumberger research fellow. He received MIT Martin Fellowship, NSF CAREER Award, NASA Early CAREER Faculty Award, and several research and innovation awards at UH. He has published more than 140 scientific articles and holds 18 granted US patents. He is a Fellow of SPIE, and serves as Associate Editor for Optica Optics Express and SPIE Journal of Nanophotonics. His research interests are biophotonics, nanobiophotonics, imaging & spectroscopy, micro/nanofabrication, and machine learning. His current research focus is on exosome-based cancer and Alzheimer’s disease diagnostics supported by NIH and DoD. Dr. Shih has started multiple companies based on his technologies. Most recently, he co-founded Seek Diagnostics (www.seekdiagnostix.com) to commercialize nanobiophotonic liquid biopsy technology.
William K. Decker, Professor, Baylor College of Medicine

William Decker Biographical Sketch
Dr. William Decker is a Professor in the Department of Pathology & Immunology at Baylor College of Medicine. Dr. Decker received a B.S. in Biology from Tufts University and a Ph.D. in Molecular in Human Genetics from Baylor College of Medicine in 2001. Fol-lowing early career work in industry, he spent seven years as Sen-ior Research Scientist in the Department of Stem Cell Transplan-tation and Cellular Therapy at the University of Texas M.D. Ander-son Cancer Center where he studied basic dendritic cell biology, transplant immunology, and developed cell-based treatment strategies for cancer. In 2011, Dr. Decker joined the faculty at Baylor College of Medicine, establishing a research group that studies basic dendritic cell immunobiology and maintains basic, translational, and clinical immunotherapy research programs for a variety of different can-cers. He has been a spon-sor/investigator on multiple INDs and holds multiple patents in the space. He additional serves as a scientific and medical advi-sor of Diakonos Oncology, a clinical-stage immuno-oncology company he co-founded, that is currently performing pivotal ran-domized trials in cell-based immunotherapy for the treatment of glioblastoma.
Yi-Ping Li, Professor, Department of Integrative Biology and Pharmacology, UTHealth Houston

Yi-Ping Li Biographical Sketch
Professor Yi-Ping Li, Ph.D. is a biomedical researcher based in Houston, Texas. He received his Ph.D. degree and postdoctoral training as well as developed his scientific research career all in Texas institutions. His research has been continuously supported by the National Institute of Health for over two decades. His recent research has been focused on the molecular mechanisms of cancer induction of skeletal muscle wasting (cachexia). His lab discovered the critical role of extracellular vesicles released by certain types of cancer cells in the induction of cachexia.
Ziwen Wang, Field Application Scientist, EXODUS BIO

Ziwen Wang Biographical Sketch
Dr. Ziwen Wang is a Field Application Scientist at EXODUS Bio, focusing on technical applications of novel nanoparticle purification technology with academic, biotech or biopharma clients. He received his B.S. degree in Bioengineering from University of Washington and a Ph.D. in Bioengineering with Prof. Shuming Nie at University of Illinois at Urbana-Champaign. His research explores diverse functional nanostructures in cancer imaging and fluorescence image-guided surgery with strong emphasis on surface ligand design and purification process development.
08:00
1 December 2025
Kleberg Auditorium
Participants Check-In
Conference Check-In and Networking
09:00
1 December 2025
Kleberg Auditorium
Conference Chair Welcome

Bruna Corradetti, Assistant Professor, Center for Precision Environmental Health, Department of Medicine, Baylor College of Medicine -- Conference Chairperson
Welcome and Introduction by Conference Chairperson + Conference Themes and Topics Addressed
09:14
1 December 2025
Kleberg Auditorium
Session Title: Session I: Extracellular Vesicles in Cancer and Immunology
09:15
1 December 2025
Kleberg Auditorium
Keynote Speaker

George A. Calin, Chair, Department of Cancer Biology Department, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, Texas
miRacles of Cell-to-Cell Communication in Cancer
09:45
1 December 2025
Kleberg Auditorium

Yi-Ping Li, Professor, Department of Integrative Biology and Pharmacology, UTHealth Houston
Cancer Cell-released Extracellular Vesicles Mediate Cachexia
Cancer-associated cachexia (cancer cachexia) is a major contributor to the modality and mortality of a wide variety of solid tumors. Cachexia takes place in approximately ~60% of cancer patients and is the immediate cause of ~30% of cancer-related death. However, there is no established treatment of this disorder due to the poor understanding of its underlying etiology. The key manifestations of cancer cachexia are systemic inflammation and progressive loss of skeletal muscle mass and function (muscle wasting). A number of inflammatory cytokines and members of the TGF superfamily that promote muscle protein degradation have been implicated as mediators of muscle wasting. However, clinical trials targeting some of the identified mediators have not been successful. We have discovered a novel mechanism of cancer cachexia. Systemic activation of Toll-like receptor 4 (TLR4) by cancer-released extracellular vesicles (EVs) that carry surface Hsp70 and Hsp90 as DAMPs are critical to the development and progression of muscle wasting, by stimulating muscle protein degradation through the ubiquitin-proteasome and the autophagy-lysosome pathways. Consequently, cancer cachexia can be intervened by targeting cancer cell released EVs.
10:05
1 December 2025
Kleberg Auditorium

Kate McAndrews, Assistant Professor, Department of Cancer Biology, MD Anderson Cancer Center, United States of America
CD9+ Extracellular Vesicles Instigate Generation of Myeloid-derived Suppressor Cells to Promote Pancreas Cancer Recalcitrance to Immunotherapy
Tumors develop as a complex network of malignant cells and stromal cells, with intercellular communication between them critical for cancer progression. Extracellular vesicles (EVs) have been proposed as putative mediators of intercellular communication in cancer; however, mechanistic studies remain unaddressed. Here, we describe the creation of genetically engineered mouse models (GEMMs) that enable fate mapping of EVs under physiological conditions and in the background of autochthonous models of pancreatic ductal adenocarcinoma (PDAC). We demonstrate that cancer cell secreted EVs marked by the tetraspanin CD9 (CD9+ ccEVs) exhibit distinct protein cargo and preferentially accumulate in a subset of myeloid cells, fibroblasts, and granulocytes. ccEV accumulation resulted in an altered transcriptional state reflective of a CD206+ immunosuppressive myeloid phenotype mediated by CXCL5 delivered by CD9+ ccEVs. Genetic inhibition of ccEV release suppressed the accumulation of immunosuppressive CD206+ myeloid cells and enabled the efficacy of immune checkpoint blockade (ICB), which can be reversed with administration of CD9+ ccEVs. Collectively, this study identifies a defining role for EVs in mediating the immunosuppressive microenvironment of PDAC and suggests that targeting ccEV release can prime therapeutic efficacy of ICB.
10:25
1 December 2025
Kleberg Auditorium

William K. Decker, Professor, Baylor College of Medicine, United States of America
Partitioning the Immunostimulatory and Immunoinhibitory Func-tions of Dendritic Cell-Secreted Extracellular Vesicles
Dendritic cells (DC) are the master regulators of the mammalian adaptive immune response, carefully governing through a complex interplay of signaling events that mediate downstream effector responses. In addition to direct cell-to-cell contact with effectors, DC release extracellular vesicles (EV), encapsulated, cargo-filled trans-port vehicles that also significantly contribute to modulation of immune function. Here we describe DC-secreted EV phenotype and function following stratification by surface expression of CTLA-4, one of the most functionally critical immune checkpoint proteins. The findings establish DC-derived CTLA-4+ and CTLA-4neg EV as novel and distinct regulators of T-cell responses, with substantial implication toward a better understanding of adaptive immune regulation and development of novel immune-based therapies.
10:55
1 December 2025
Exhibits
Mid-Morning Break -- Network with Colleagues and Exhibitors
11:19
1 December 2025
Kleberg Auditorium
Session Title: Session II: Emerging Technologies for EV Characterization and Detection
11:40
1 December 2025
Kleberg Auditorium

Wei-Chuan Shih, Cullen Engineering Endowed Professor, University of Houston; Founder-CEO, Seek Diagnostics, United States of America
Isolation-free Nanophotonic Single Exosome Profiling for Cancer Biomarker Validation and Early Cancer Detection
Blood-circulating cancer exosome is an emerging biomarker for cancer detection. However, most existing techniques require exosome isolation and cannot provide single exosome information. I will talk about our isolation-free nanophotonic single exosome profiling technique that does not require PCR or DNA sequencing. We have demonstrated that plasmonic nano-aperture label-free imaging (PANORAMA) can detect single nanoparticle down to sub-10 nm. The co-acquisition of PANORAMA and fluorescence images enables label-free visualization, enumeration, size determination, and profiling of cargo microRNAs (miRs) and surface proteins. Our recent study revealed a threshold level of plasma exosome counts that can be used to distinguish cancer patients from healthy volunteers regardless of cancer type and stages. Using this threshold and additional molecular profiling, we have demonstrated sensitivity and specificity both over 90% in detecting liver cancer. Our platform can provide high-throughput exosomal biomarker profiling and validation from clinical samples directly. It is particularly suited for point-of-care applications when only 20 microliter of plasma is needed.
12:00
1 December 2025
Kleberg Auditorium
Technology Spotlight Presentation

Ziwen Wang, Field Application Scientist, EXODUS BIO, United States of America
Accelerating Extracellular Vesicle Research & Development with EXODUS Purification Technology
EXODUS is an automatic exosome isolation system with high yield and high purity from a variety of biological samples. This innovative approach combines negative pressure oscillation with double-coupled ultrasonic harmonic oscillation. EXODUS offers versatile label-free solutions to extracellular vesicle isolation with rapid processing time and reproducible results. It has demonstrated great potential in nanoparticle purification, biomarker detection and diagnostics, innovative drug delivery and therapeutics in biomedical research and clinical translation.
12:20
1 December 2025
Lunch Break
13:19
1 December 2025
Kleberg Auditorium
Session Title: Session III: Lipid Nanoparticles (LNPs) and Biomimetic Platforms
13:20
1 December 2025
Kleberg Auditorium

Francesca Taraballi, Associate Professor of Orthopedic Surgery, Houston Methodist Research Institute
Biomimetic Nanoparticles, Applications and Translation
Biomimetic nanoparticles (BNPs) harness nature-inspired designs to enhance therapeutic delivery, targeting, and immune modulation. By replicating the structural and functional features of biological systems, BNPs can improve circulation time, evade immune clearance, and home to disease sites with high specificity. Applications span oncology, regenerative medicine, infectious diseases, and diagnostics, delivering cargos ranging from mRNA and proteins to small molecules. While preclinical data demonstrate remarkable efficacy, successful translation requires addressing manufacturing scalability, batch-to-batch consistency, regulatory classification, and long-term safety. BNPs stand at the intersection of nanotechnology and translational medicine, offering a powerful platform to bridge laboratory innovation with clinical impact.
13:45
1 December 2025
Kleberg Auditorium

Sara Corvigno, Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson, United States of America
Lipid and Plant-derived Vesicles as Delivery Systems in Cancer Therapy
Lipid nanoparticles are an effective way to deliver bioactive compounds systemically. Plant-derived vesicles might be an even superior vehicle, with an added value in cancer therapeutics.
14:05
1 December 2025
Kleberg Auditorium

Biana Godin, Associate Professor, Department of Nanomedicine, Houston Methodist Research Institute, United States of America
Title to be Confirmed
14:25
1 December 2025
Kleberg Auditorium

Kelsey Swingle, Assistant Professor, Department of Bioengineering, Rice University, United States of America
Engineering Placenta-tropic Lipid Nanoparticles for the Treatment of Pregnancy Disorders
Despite significant advances in science and medicine over the last two decades, maternal mortality rates have been on the rise, with the United States having one of the highest maternal mortality rates compared to other industrialized nations across the globe. This can be partially explained by the lack of therapeutics to treat obstetric disorders during pregnancy such as pre-eclampsia, for which there is no therapeutic available in the clinic to slow disease progression. In this talk, I will share my research efforts towards the design and evaluation of an mRNA lipid nanoparticle (LNP) therapeutic to treat pre-eclampsia. Given that pre-eclampsia is a placental insufficiency disorder, I will describe efforts to engineer a placenta-tropic LNP formulation that enables delivery of therapeutic vascular endothelial growth factor (VEGF) mRNA to restore blood flow in the placenta for the treatment of pre-eclampsia. For this placenta-tropic formulation identified via high-throughput in vivo screening, I will propose an endogenous targeting mechanism that enables LNP delivery to the placenta upon systemic administration. Finally, I will share results demonstrating that a single injection of this VEGF mRNA LNP therapeutic ameliorates maternal hypertension and improves fetal health in multiple mouse models of pre-eclampsia. Together, these promising results suggest the potential to engineer nucleic acid LNP therapeutics for placental disorders such as pre-eclampsia.
15:05
1 December 2025
Exhibits
Mid-Afternoon Break and Networking with the Exhibitors
15:35
1 December 2025
Exhibits
Instrument Demo
EXODUS BIO Onsite Instrument Demo
16:05
1 December 2025
Exhibits
Instrument Demo
Particle Metrix Onsite Instrumentation Demo
16:35
1 December 2025
Kleberg Auditorium

Session Title: Young Investigator Presentations Session I
17:35
1 December 2025
Kleberg Auditorium
Discussion / Wrap-Up
18:00
1 December 2025
Close of Day 1 of the Conference
08:00
2 December 2025
Kleberg Auditorium
Conference Day 2 Opens
09:00
2 December 2025
Kleberg Auditorium
Professor Bruna Corradetti -- Chairperson Recap of Day 1 and Objectives for Day 2
09:14
2 December 2025
Kleberg Auditorium
Session Title: Session IV: EV Biomarkers and Prenatal Medicine
09:15
2 December 2025
Kleberg Auditorium

Laura Goetzl, Professor and Vice Chair for Translational Research, The University of Texas, MD Anderson Caner Center
Extracellular Vesicle Biomarkers in Perinatal Medicine: Translational Potential
EVs as non-invasive biomarkers of fetal, neonatal and maternal brain health. Results from translational studies will be presented to demonstrate areas of potential collaborative research with clinical and pre-clinical investigators.
09:40
2 December 2025
Kleberg Auditorium
Kammala
Preterm Birth
10:00
2 December 2025
Kleberg Auditorium

Jacqueline Parchem, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, UTHealth Houston, United States of America
Amniotic Fluid Extracellular Vesicles: Insights into Fetal Adaptations to Cardiovascular Stress
Molecular analyses of amniotic fluid offer a unique window into human fetal development and disease. Using twin-twin transfusion syndrome as a model of fetal cardiovascular stress, we identified signatures of fetal metabolic adaptation through extracellular vesicle mRNA profiling and metabolomics.
10:20
2 December 2025
Kleberg Auditorium

Bruna Corradetti, Assistant Professor, Center for Precision Environmental Health, Department of Medicine, Baylor College of Medicine, United States of America
EVs as Minimally Invasive Strategies for Congenital Malformations
10:40
2 December 2025
Exhibits
Mid-Morning Break -- Network with Colleagues and Engage with the Exhibitors
11:10
2 December 2025
Kleberg Auditorium

Session Title: Young Investigators Presentation Session II
12:10
2 December 2025
Lunch Break
13:09
2 December 2025
Kleberg Auditorium
Session Title: Session V: EVs in Immunity, Infection, and Disease Microenvironments
13:10
2 December 2025
Kleberg Auditorium
Devika S. Manickam
Delivery of Mitochondria-Containing Extracellular Vesicles to the BBB and Spinal Cord
13:30
2 December 2025
Kleberg Auditorium

Swathi Balaji, Associate Professor, Baylor College of Medicine and Texas Children’s Hospital, United States of America
Regulation of Fibroblast Exosome Production by Mechanical Tension Influences Scarring Heterogeneity
Dermal injury repair occurs via fibroblast-mediated scar formation, which is potentiated by mechanical tension. Fibrosis and physiologic scarring after similar injuries vary greatly among patients resulting in a spectrum of phenotypes from low to high scarring. However, the regulation of scar variability and the pro-fibrotic signaling mechanisms of fibroblasts are not well understood. Extracellular vesicles (exosomes) regulate intra- and inter-cellular communication to govern fibrosis. Our studies demonstrate that fibroblasts isolated from the abdominal skin of healthy patients from different scarring phenotypes, who were stratified based on the clinical stratification of their prior existing surgical scars in similar location, respond differentially to tension, including changes in exosome production and cargo that could influence fibrogenic phenotype. Mining these exosome profiles further and how they regulate intra-cellular signaling to govern scar-phenotypes will reveal fundamental biologic differences underlying heterogeneity in human scarring and lead to novel anti-scar therapeutics.
13:50
2 December 2025
Kleberg Auditorium

Tiziana Corsello, Assistant Professor, Department of Pediatrics, CEIID Research, University of Texas Medical Branch
Tiny Messengers, Big Impact: Extracellular Vesicles Linking Viruses and Airway Disease
Respiratory syncytial virus (RSV) is a leading cause of respiratory illness in children. While new antibody-based preventive strategies can reduce severe lower airway disease, no vaccine is available for infants to prevent upper airway infection, and no specific antiviral therapy exists. Our research has identified extracellular vesicle proteins from airway cells in children that play a role in RSV infection. We aim to advance the understanding of extracellular vesicles in RSV and other pediatric viral infections, laying the groundwork for vesicle-based antiviral strategies.
14:10
2 December 2025
Kleberg Auditorium

Fernanda G. Kugeratski, Instructor, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, United States of America
Proteomic-based Characterization of the Cancer-associated Fibroblast Secretome Unravels New Players with Immunoregulatory and Pro-angiogenic Functions
This presentation will focus on the proteomic characterization of the extracellular vesicles and soluble secretome derived from hypoxic and normoxic cancer-associated fibroblasts and endothelial cells. Additionally, it will describe the functional role of selected targets in the modulation of immunoregulatory and pro-angiogenic functions of the tumor microenvironment.
14:30
2 December 2025
Kleberg Auditorium

Trainees Prize Award (Sponsored by Biology Open)
14:45
2 December 2025
Kleberg Auditorium

Carly Filgueira, Assistant Professor of Nanomedicine & Cardiovascular Surgery, Houston Methodist Research Institute, United States of America
Nanodisc Design for Kinetic Assessments of Membrane Protein Interactions for Insights into Antibiotic Resistance
Understanding the molecular mechanisms directing protein complexation and antibiotic binding is essential for advancing antimicrobial stewardship and combinatorial therapy strategies against resistance. Many of the key proteins participating in these mechanisms are embedded within cellular membranes, presenting significant experimental hurdles owing to their hydrophobic nature and complex, dynamic assemblies. To address these challenges, nanodiscs, a platform consisting of soluble, discoidal lipid bilayers stabilized by scaffold proteins, have emerged as a transformative tool for membrane protein structural and functional studies. Nanodiscs enable researchers to stabilize membrane proteins in a near-native lipid environment, which preserves biological activity and proper folding far better than traditional detergent-based methods.
In this work, penicillin binding protein 4 (PBP4) was incorporated into nanodiscs to dissect its interactions with truncated and full-length LiaX, an effector of the “seesaw effect” that modulates resistance in Enterococcus faecalis. The domains of LiaX that directly bind PBP4 and govern antibiotic affinity remain unknown. We hypothesize that full-length LiaX exerts unique regulatory influence over PBP4’s affinity for β-lactam antibiotics. We show that the 75 kDa solubilized PBP4 protein has a melting temperature 59.03 ± 0.06 °C, which increases to 60.97 ± 0.02 °C in nanodiscs, indicating enhanced thermal stability from lipid bilayer incorporation. Occupied PBP4-nanodiscs exhibit mean radii of 7.66 ± 0.21 nm, substantially larger than empty nanodiscs. Both solubilized PBP4 and PBP4 in nanodiscs retain β-lactam binding activity, confirmed by BOC-FL assays. Surface plasmon resonance shows that full-length LiaX binds PBP4-nanodiscs with a Kd of 760 nM and a slow dissociation rate, while N-terminal LiaX binds faster but with lower affinity. The extended association time of FL-LiaX with PBP4 (489 s vs. 0.37 s for Nt-LiaX) underscores crucial regulatory effects. Ultimately, unveiling these membrane-driven molecular details could pave the way for therapies that improve clinical outcomes while reducing hospital stays and healthcare expenditures.
15:00
2 December 2025
Kleberg Auditorium

Surjya Dash, Senior Scientist, Department of Nephrology, School of Medicine, University of Virginia, United States of America
Emerging Therapeutic Avenues in Diabetes: The Big Potential of Tiny Blebs
15:30
2 December 2025
Kleberg Auditorium

Theocharis Panaretakis, Associate Professor, GU Medical Oncology, MD Anderson Cancer Center, United States of America
Monitoring Prostate Cancer in Circulation
Lethal prostate cancer (PCa) frequently progresses to treatment-resistant disease in bone, where current methods for monitoring bone metastases remain limited. In this study, we evaluated plasma-derived extracellular vesicles (EVs) as a noninvasive approach to monitor tumor-induced changes in the bone tumor microenvironment (bone-TME) in men with bone-metastatic PCa (bmPCa). Transcriptomic analysis of plasma EVs identified a distinct “bone metastasis signature” (BMS) that reflects the characteristic tumor-driven bone formation seen in bmPCa. In preclinical models, BMS genes were enriched in EVs from mice bearing bone-metastatic tumors, but not in those with adrenal-metastatic tumors. Longitudinal profiling revealed that BMS markers increased prior to detectable bone-forming tumor growth. Furthermore, dynamic monitoring of BMS in EVs from tumor-bearing mice treated with the bone-targeting agent Ra-223 showed that the BMS can be used to monitor treatment response. These co-clinical findings support the utility of the EV-derived BMS as a tool for longitudinal monitoring of bone metastatic PCa and therapeutic response.
16:00
2 December 2025
Close of Conference




